Sentrin-specific protease

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	**[[3eay]] – hSenp7 catalytic domain + SUMO1<br />		**[[3eay]] – hSenp7 catalytic domain + SUMO1<br />
		+	**[[7r2e]] – hSenp7 catalytic domain + SUMO2<br />
	*Sentrin-specific protease 8		*Sentrin-specific protease 8

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Revision as of 08:21, 15 November 2023

spinqualitylabelsall models Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry 2iy0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Sentrin-specific protease 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide[1]. (PDB entry 2iy0).

3D structures of sentrin-specific protease

Updated on 15-November-2023

References

1. ↑ Lee WP, Jena S, Doherty D, Ventakesh J, Schimdt J, Furmick J, Widener T, Lemau J, Jurutka PW, Thompson PD. Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling. PLoS One. 2014 Feb 20;9(2):e89506. doi: 10.1371/journal.pone.0089506. eCollection, 2014. PMID:24586832 doi:http://dx.doi.org/10.1371/journal.pone.0089506