1o9m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1o9m.gif|left|200px]]
[[Image:1o9m.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1o9m |SIZE=350|CAPTION= <scene name='initialview01'>1o9m</scene>, resolution 2.4&Aring;
+
The line below this paragraph, containing "STRUCTURE_1o9m", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:42b+Binding+Site+For+Chain+B'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=42B:4-AMINO-2-HYDROXYBUTANOIC+ACID'>42B</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=BDG:O-2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSE'>BDG</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=P24:1-(AMINOETHYL)AMINO-4-AMINOBUTANE'>P24</scene>, <scene name='pdbligand=PA2:PAROMOMYCIN+(RING+2)'>PA2</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1o9m| PDB=1o9m | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o9m OCA], [http://www.ebi.ac.uk/pdbsum/1o9m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o9m RCSB]</span>
+
-
}}
+
'''THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.'''
'''THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
1O9M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9M OCA].
+
1O9M is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9M OCA].
==Reference==
==Reference==
Line 26: Line 23:
[[Category: Murray, J B.]]
[[Category: Murray, J B.]]
[[Category: Russell, R.]]
[[Category: Russell, R.]]
-
[[Category: a-site]]
+
[[Category: A-site]]
-
[[Category: rna-antibiotic interaction]]
+
[[Category: Rna-antibiotic interaction]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:33:44 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:41:56 2008''
+

Revision as of 00:33, 3 May 2008

Image:1o9m.gif

Template:STRUCTURE 1o9m

THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.


Overview

The ribosome is an important target for aminoglycoside antibiotics; however, the clinical effectiveness of aminoglycosides has diminished due to bacterial resistance mechanisms. Here we report the X-ray structure of a novel synthetic aminoglycoside bound to the A site of the ribosome, its target for manifestation of activity. The structure validates the in silico design paradigms for the antibiotic and reveals the molecular interactions made by this novel antibiotic in prokaryotes.

About this Structure

1O9M is a Single protein structure. Full crystallographic information is available from OCA.

Reference

The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography., Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S, J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:12643685 Page seeded by OCA on Sat May 3 03:33:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o9m"
Personal tools