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5qgx

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Current revision (09:55, 15 November 2023) (edit) (undo)
 
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<StructureSection load='5qgx' size='340' side='right'caption='[[5qgx]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
<StructureSection load='5qgx' size='340' side='right'caption='[[5qgx]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5qgx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QGX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5qgx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QGX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H2J:N-(3-chlorophenyl)-2-(4-methoxyphenyl)acetamide'>H2J</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H2J:N-(3-chlorophenyl)-2-(4-methoxyphenyl)acetamide'>H2J</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qgx OCA], [http://pdbe.org/5qgx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qgx RCSB], [http://www.ebi.ac.uk/pdbsum/5qgx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qgx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qgx OCA], [https://pdbe.org/5qgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qgx RCSB], [https://www.ebi.ac.uk/pdbsum/5qgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qgx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN]] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).
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[https://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aimon, A]]
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[[Category: Aimon A]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Bradley, A R]]
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[[Category: Bradley AR]]
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[[Category: Brandao-Neto, J]]
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[[Category: Brandao-Neto J]]
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[[Category: Brennan, P E]]
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[[Category: Brennan PE]]
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[[Category: Collins, P]]
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[[Category: Collins P]]
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[[Category: Delft, F von]]
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[[Category: Diaz Saez L]]
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[[Category: Douangamath, A]]
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[[Category: Douangamath A]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Elkins, J]]
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[[Category: Elkins J]]
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[[Category: Fairhead, M]]
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[[Category: Fairhead M]]
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[[Category: Huber, K]]
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[[Category: Huber K]]
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[[Category: Krojer, T]]
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[[Category: Krojer T]]
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[[Category: London, N]]
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[[Category: London N]]
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[[Category: Nelson, A]]
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[[Category: Nelson A]]
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[[Category: Ruda, G F]]
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[[Category: Ruda GF]]
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[[Category: Saez, L Diaz]]
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[[Category: Spencer J]]
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[[Category: Spencer, J]]
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[[Category: Srikannathasan V]]
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[[Category: Srikannathasan, V]]
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[[Category: Szommer T]]
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[[Category: Szommer, T]]
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[[Category: Talon R]]
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[[Category: Talon, R]]
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[[Category: Von Delft F]]
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[[Category: Hydrolase]]
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[[Category: Nudix domain]]
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[[Category: Pandda]]
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[[Category: Sgc - diamond i04-1 fragment screening]]
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[[Category: Xchemexplorer]]
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Current revision

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000155

PDB ID 5qgx

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