1o9u

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[[Image:1o9u.gif|left|200px]]
[[Image:1o9u.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1o9u |SIZE=350|CAPTION= <scene name='initialview01'>1o9u</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1o9u", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Adz+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADZ:9-METHYL-9H-PURIN-6-AMINE'>ADZ</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1o9u| PDB=1o9u | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o9u OCA], [http://www.ebi.ac.uk/pdbsum/1o9u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o9u RCSB]</span>
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}}
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'''GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE'''
'''GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE'''
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[[Category: Pearl, L H.]]
[[Category: Pearl, L H.]]
[[Category: Roe, S M.]]
[[Category: Roe, S M.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: anti-oncogene]]
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[[Category: Anti-oncogene]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: developmental protein]]
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[[Category: Developmental protein]]
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[[Category: insulin pathway]]
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[[Category: Insulin pathway]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: multigene family]]
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[[Category: Multigene family]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: serine/threonine -protein kinase]]
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[[Category: Serine/threonine -protein kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:34:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:42:02 2008''
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Revision as of 00:34, 3 May 2008

Image:1o9u.gif

Template:STRUCTURE 1o9u

GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE


Overview

Glycogen synthase kinase 3beta (GSK3beta) is a serine/threonine kinase involved in insulin, growth factor and Wnt signalling. In Wnt signalling, GSK3beta is recruited to a multiprotein complex via interaction with axin, where it hyperphosphorylates beta-catenin, marking it for ubiquitylation and destruction. We have now determined the crystal structure of GSK3beta in complex with a minimal GSK3beta-binding segment of axin, at 2.4 A resolution. The structure confirms the co-localization of the binding sites for axin and FRAT in the C-terminal domain of GSK3beta, but reveals significant differences in the interactions made by axin and FRAT, mediated by conformational plasticity of the 285-299 loop in GSK3beta. Detailed comparison of the axin and FRAT GSK3beta complexes allows the generation of highly specific mutations, which abrogate binding of one or the other. Quantitative analysis suggests that the interaction of GSK3beta with the axin scaffold enhances phosphorylation of beta-catenin by >20 000-fold.

About this Structure

1O9U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex., Dajani R, Fraser E, Roe SM, Yeo M, Good VM, Thompson V, Dale TC, Pearl LH, EMBO J. 2003 Feb 3;22(3):494-501. PMID:12554650 Page seeded by OCA on Sat May 3 03:34:10 2008

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OCA

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