7qtq
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7qtq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QTQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[7qtq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QTQ FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=T44:3,5,3,5-TETRAIODO-L-THYRONINE'>T44</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qtq OCA], [https://pdbe.org/7qtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qtq RCSB], [https://www.ebi.ac.uk/pdbsum/7qtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qtq ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qtq OCA], [https://pdbe.org/7qtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qtq RCSB], [https://www.ebi.ac.uk/pdbsum/7qtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qtq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/THYG_BOVIN THYG_BOVIN] Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity).[UniProtKB:F1RRV3][UniProtKB:O08710][UniProtKB:P01266] | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Marechal | + | [[Category: Marechal N]] |
| - | [[Category: Serrano | + | [[Category: Serrano BP]] |
| - | [[Category: Weitz | + | [[Category: Weitz JC]] |
| - | [[Category: Zhang | + | [[Category: Zhang X]] |
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Current revision
Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids.
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