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2l8t

From Proteopedia

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Revision as of 12:13, 15 November 2023

Staphylococcus aureus pathogenicity island 1 protein gp6, an internal scaffold in size determination

Structural highlights

2l8t is a 2 chain structure with sequence from Staphylococcus aureus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O54465_STAAU

Publication Abstract from PubMed

Staphylococcus aureus pathogenicity island 1 (SaPI1) is a mobile genetic element that carries genes for several superantigen toxins. SaPI1 is normally stably integrated into the host genome but can become mobilized by "helper" bacteriophage 80alpha, leading to the packaging of SaPI1 genomes into phage-like transducing particles that are composed of structural proteins supplied by the helper phage but having smaller capsids. We show that the SaPI1-encoded protein gp6 is necessary for efficient formation of small capsids. The NMR structure of gp6 reveals a dimeric protein with a helix-loop-helix motif similar to that of bacteriophage scaffolding proteins. The gp6 dimer matches internal densities that bridge capsid subunits in cryo-electron microscopy reconstructions of SaPI1 procapsids, suggesting that gp6 acts as an internal scaffolding protein in capsid size determination.

The Staphylococcus aureus Pathogenicity Island 1 Protein gp6 Functions as an Internal Scaffold during Capsid Size Determination.,Dearborn AD, Spilman MS, Damle PK, Chang JR, Monroe EB, Saad JS, Christie GE, Dokland T J Mol Biol. 2011 Sep 30;412(4):710-22. Epub 2011 Jul 29. PMID:21821042^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Dearborn AD, Spilman MS, Damle PK, Chang JR, Monroe EB, Saad JS, Christie GE, Dokland T. The Staphylococcus aureus Pathogenicity Island 1 Protein gp6 Functions as an Internal Scaffold during Capsid Size Determination. J Mol Biol. 2011 Sep 30;412(4):710-22. Epub 2011 Jul 29. PMID:21821042 doi:10.1016/j.jmb.2011.07.036

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l8t"

@@ Line 1: / Line 1: @@
 ==Staphylococcus aureus pathogenicity island 1 protein gp6, an internal scaffold in size determination==
-<StructureSection load='2l8t' size='340' side='right'caption='[[2l8t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2l8t' size='340' side='right'caption='[[2l8t]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2l8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8T FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2l8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8T FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8t OCA], [https://pdbe.org/2l8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8t RCSB], [https://www.ebi.ac.uk/pdbsum/2l8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8t ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8t OCA], [https://pdbe.org/2l8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8t RCSB], [https://www.ebi.ac.uk/pdbsum/2l8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8t ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/O54465_STAAU O54465_STAAU]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Chang, J R]]
+[[Category: Staphylococcus aureus]]
-[[Category: Christie, G E]]
+[[Category: Chang JR]]
-[[Category: Damle, P K]]
+[[Category: Christie GE]]
-[[Category: Dearborn, A D]]
+[[Category: Damle PK]]
-[[Category: Dokland, T]]
+[[Category: Dearborn AD]]
-[[Category: Monroe, E B]]
+[[Category: Dokland T]]
-[[Category: Saad, J S]]
+[[Category: Monroe EB]]
-[[Category: Spilman, M S]]
+[[Category: Saad JS]]
-[[Category: Bacteriophage]]
+[[Category: Spilman MS]]
-[[Category: Sapi]]
-[[Category: Scaffold]]
-[[Category: Structural protein]]

2l8t

From Proteopedia

Revision as of 12:13, 15 November 2023

Staphylococcus aureus pathogenicity island 1 protein gp6, an internal scaffold in size determination

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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