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1oan

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[[Image:1oan.gif|left|200px]]
[[Image:1oan.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1oan |SIZE=350|CAPTION= <scene name='initialview01'>1oan</scene>, resolution 2.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1oan", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Afl+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1oan| PDB=1oan | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oan OCA], [http://www.ebi.ac.uk/pdbsum/1oan PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oan RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN'''
'''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN'''
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[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Modis, Y.]]
[[Category: Modis, Y.]]
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[[Category: dengue virus]]
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[[Category: Dengue virus]]
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[[Category: flavivirus]]
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[[Category: Flavivirus]]
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[[Category: fusion peptide]]
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[[Category: Fusion peptide]]
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[[Category: low-ph conformational change]]
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[[Category: Low-ph conformational change]]
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[[Category: membrane fusion]]
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[[Category: Membrane fusion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:36:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:42:27 2008''
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Revision as of 00:36, 3 May 2008

Image:1oan.gif

Template:STRUCTURE 1oan

CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN


Overview

Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a beta-hairpin at the interface between two domains. These features point to a structural pathway for the fusion-activating transition and suggest a strategy for finding small-molecule inhibitors of dengue and other flaviviruses.

About this Structure

1OAN is a Single protein structure of sequence from Dengue virus 2. Full crystallographic information is available from OCA.

Reference

A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:12759475 Page seeded by OCA on Sat May 3 03:36:02 2008

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