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1pdg
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(New page: 200px<br /> <applet load="1pdg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pdg, resolution 3.0Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 16:35, 12 November 2007
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CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB
Contents |
Overview
The crystal structure of the homodimeric BB isoform of human recombinant, platelet-derived growth factor (PDGF-BB) has been determined by X-ray, analysis to 3.0 A resolution. The polypeptide chain is folded into two, highly twisted antiparallel pairs of beta-strands and contains an unusual, knotted arrangement of three intramolecular disulfide bonds. Dimerization, leads to the clustering of three surface loops at each end of the, elongated dimer, which most probably form the receptor recognition sites.
Disease
Known diseases associated with this structure: Dermatofibrosarcoma protuberans OMIM:[190040], Giant-cell fibroblastoma OMIM:[190040], Meningioma, SIS-related OMIM:[190040]
About this Structure
1PDG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human platelet-derived growth factor BB., Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M, EMBO J. 1992 Nov;11(11):3921-6. PMID:1396586
Page seeded by OCA on Mon Nov 12 18:42:23 2007
