1oao

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[[Image:1oao.jpg|left|200px]]
[[Image:1oao.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1oao |SIZE=350|CAPTION= <scene name='initialview01'>1oao</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1oao", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+D'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=FLH:FORMALDEHYDE'>FLH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX:SULFUR+OXIDE'>SX</scene>, <scene name='pdbligand=XCC:FE(4)-NI(1)-S(4)+CLUSTER'>XCC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbon-monoxide_dehydrogenase_(acceptor) Carbon-monoxide dehydrogenase (acceptor)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.99.2 1.2.99.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1oao| PDB=1oao | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oao OCA], [http://www.ebi.ac.uk/pdbsum/1oao PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oao RCSB]</span>
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}}
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'''NIZN[FE4S4] AND NINI[FE4S4] CLUSTERS IN CLOSED AND OPEN ALPHA SUBUNITS OF ACETYL-COA SYNTHASE/CARBON MONOXIDE DEHYDROGENASE'''
'''NIZN[FE4S4] AND NINI[FE4S4] CLUSTERS IN CLOSED AND OPEN ALPHA SUBUNITS OF ACETYL-COA SYNTHASE/CARBON MONOXIDE DEHYDROGENASE'''
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==Reference==
==Reference==
Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] clusters in closed and open subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase., Darnault C, Volbeda A, Kim EJ, Legrand P, Vernede X, Lindahl PA, Fontecilla-Camps JC, Nat Struct Biol. 2003 Apr;10(4):271-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12627225 12627225]
Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] clusters in closed and open subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase., Darnault C, Volbeda A, Kim EJ, Legrand P, Vernede X, Lindahl PA, Fontecilla-Camps JC, Nat Struct Biol. 2003 Apr;10(4):271-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12627225 12627225]
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[[Category: Carbon-monoxide dehydrogenase (acceptor)]]
 
[[Category: Moorella thermoacetica]]
[[Category: Moorella thermoacetica]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Vernede, X.]]
[[Category: Vernede, X.]]
[[Category: Volbeda, A.]]
[[Category: Volbeda, A.]]
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[[Category: acetyl-coa formation]]
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[[Category: Acetyl-coa formation]]
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[[Category: electron transfer]]
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[[Category: Electron transfer]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: wood/ljungdahl pathway,nickel]]
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[[Category: Wood/ljungdahl pathway,nickel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:36:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:42:30 2008''
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Revision as of 00:36, 3 May 2008

Image:1oao.jpg

Template:STRUCTURE 1oao

NIZN[FE4S4] AND NINI[FE4S4] CLUSTERS IN CLOSED AND OPEN ALPHA SUBUNITS OF ACETYL-COA SYNTHASE/CARBON MONOXIDE DEHYDROGENASE


Overview

The crystal structure of the tetrameric alpha2beta2 acetyl-coenzyme A synthase/carbon monoxide dehydrogenase from Moorella thermoacetica has been solved at 1.9 A resolution. Surprisingly, the two alpha subunits display different (open and closed) conformations. Furthermore, X-ray data collected from crystals near the absorption edges of several metal ions indicate that the closed form contains one Zn and one Ni at its active site metal cluster (A-cluster) in the alpha subunit, whereas the open form has two Ni ions at the corresponding positions. Alternative metal contents at the active site have been observed in a recent structure of the same protein in which A-clusters contained one Cu and one Ni, and in reconstitution studies of a recombinant apo form of a related acetyl-CoA synthase. On the basis of our observations along with previously reported data, we postulate that only the A-clusters containing two Ni ions are catalytically active.

About this Structure

1OAO is a Protein complex structure of sequences from Moorella thermoacetica. Full crystallographic information is available from OCA.

Reference

Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] clusters in closed and open subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase., Darnault C, Volbeda A, Kim EJ, Legrand P, Vernede X, Lindahl PA, Fontecilla-Camps JC, Nat Struct Biol. 2003 Apr;10(4):271-9. PMID:12627225 Page seeded by OCA on Sat May 3 03:36:10 2008

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