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5n81

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Current revision (12:33, 15 November 2023) (edit) (undo)
 
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==Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog==
==Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog==
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<StructureSection load='5n81' size='340' side='right' caption='[[5n81]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='5n81' size='340' side='right'caption='[[5n81]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n81]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10027 Atcc 10027]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N81 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N81 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Q2:[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl+~{N}-[(3~{S})-3-azanyl-3-(4-prop-2-ynoxyphenyl)propanoyl]sulfamate'>8Q2</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tycA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54914 ATCC 10027])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8Q2:[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl+~{N}-[(3~{S})-3-azanyl-3-(4-prop-2-ynoxyphenyl)propanoyl]sulfamate'>8Q2</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_racemase_(ATP-hydrolyzing) Phenylalanine racemase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.11 5.1.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n81 OCA], [https://pdbe.org/5n81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n81 RCSB], [https://www.ebi.ac.uk/pdbsum/5n81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n81 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n81 OCA], [http://pdbe.org/5n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n81 RCSB], [http://www.ebi.ac.uk/pdbsum/5n81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n81 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TYCA_BREPA TYCA_BREPA]] In the first step of peptide synthesis this enzyme activates phenylalanine and racemizes it to the D-isomer.
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[https://www.uniprot.org/uniprot/TYCA_BREPA TYCA_BREPA] In the first step of peptide synthesis this enzyme activates phenylalanine and racemizes it to the D-isomer.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 10027]]
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[[Category: Brevibacillus parabrevis]]
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[[Category: Fercher, D]]
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[[Category: Large Structures]]
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[[Category: Hansen, D A]]
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[[Category: Fercher D]]
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[[Category: Hilvert, D]]
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[[Category: Hansen DA]]
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[[Category: Kries, H]]
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[[Category: Hilvert D]]
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[[Category: Mori, T]]
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[[Category: Kries H]]
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[[Category: Niquille, D L]]
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[[Category: Mori T]]
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[[Category: Adenylation domain]]
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[[Category: Niquille DL]]
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[[Category: Ligase]]
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[[Category: Nonribosomal peptide synthetase]]
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Current revision

Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog

PDB ID 5n81

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