Serine/threonine protein kinase 3D structures

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**[[7akm]] - hChk1 kinase domain + ATP<br />
**[[7akm]] - hChk1 kinase domain + ATP<br />
-
**[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]], [[7bko]], [[8e80]] - hChk1 kinase domain + inhibitor<br />
+
**[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]], [[7bko]], [[8e80]]. ]]8o81]] - hChk1 kinase domain + inhibitor<br />
-
**[[5oot]], [[5op2]], [[5op4]], [[5op5]], [[5op7]], [[5opb]], [[5opr]], [[5ops]], [[5opu]], [[5opv]], [[5oq5]], [[5oq6]], [[5oq7]], [[5oq8]], [[7bjd]], [[7bjh]], [[7bjj]], [[7bjm]], [[7bjo]], [[7bjr]], [[7bjx]], [[7bk1]], [[7bk2]], [[7bk3]], [[7mck]], [[7suf]], [[7sug]], [[7suh]], [[7sui]], [[7suj]] - hChk1 kinase domain (mutant) + inhibitor<br />
+
**[[5oot]], [[5op2]], [[5op4]], [[5op5]], [[5op7]], [[5opb]], [[5opr]], [[5ops]], [[5opu]], [[5opv]], [[5oq5]], [[5oq6]], [[5oq7]], [[5oq8]], [[7bjd]], [[7bjh]], [[7bjj]], [[7bjm]], [[7bjo]], [[7bjr]], [[7bjx]], [[7bk1]], [[7bk2]], [[7bk3]], [[7mck]], [[7suf]], [[7sug]], [[7suh]], [[7sui]], [[7suj]], [[8siv]], [[8siw]], [[8six]] - hChk1 kinase domain (mutant) + inhibitor<br />
**[[5oop]] - hChk1 kinase domain (mutant) + AMPPNP<br />
**[[5oop]] - hChk1 kinase domain (mutant) + AMPPNP<br />
**[[5oor]] - hChk1 kinase domain (mutant) + staurosporine<br />
**[[5oor]] - hChk1 kinase domain (mutant) + staurosporine<br />
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**[[6cpf]] – hChk6 kinase domain + AMPPCP<br />
**[[6cpf]] – hChk6 kinase domain + AMPPCP<br />
**[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
**[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
-
**[[6cpg]] – hChk6 kinase domain + inhibitor + monobody<br />
+
**[[6cpg]], [[8ssp]] – hChk6 kinase domain + inhibitor + monobody<br />
-
**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]], [[6z4y]], [[7ayh]], [[7ayi]], [[7fic]] – hChk6 kinase domain + inhibitor<br />
+
**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]], [[6z4y]], [[7ayh]], [[7ayi]], [[7fic]], [[7o2v]], [[8jmx]] – hChk6 kinase domain + inhibitor<br />
**[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]], [[4jbo]], [[4jbp]], [[4jbq]], [[4prj]], [[5dpv]], [[6hjk]], [[6hjj]] – hChk6 kinase domain (mutant) + inhibitor<br />
**[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]], [[4jbo]], [[4jbp]], [[4jbq]], [[4prj]], [[5dpv]], [[6hjk]], [[6hjj]] – hChk6 kinase domain (mutant) + inhibitor<br />
**[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
**[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
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*'''Chk13 (Polo-like kinase Plk)'''
*'''Chk13 (Polo-like kinase Plk)'''
-
*Plk1 Polo-box domain (Pbd)''
+
*Plk1 Polo-box domain (Pbd) 371-594''
**[[1q4o]], [[2ogq]], [[3hih]], [[3p2w]], [[4h5x]], [[6n46]] – hPlk1 Pbd<br />
**[[1q4o]], [[2ogq]], [[3hih]], [[3p2w]], [[4h5x]], [[6n46]] – hPlk1 Pbd<br />
 +
**[[8joq]], [[8joy]] – hPlk1 Pbd + hpv peptide<br />
*Plk1 Pbd complex with polypeptide
*Plk1 Pbd complex with polypeptide
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**[[6ax4]] – hChk Plk1 + histidine cyclized macrocycle <br />
**[[6ax4]] – hChk Plk1 + histidine cyclized macrocycle <br />
**[[5x3s]] – mPlk1 + phosphopeptide<br />
**[[5x3s]] – mPlk1 + phosphopeptide<br />
 +
**[[8joq]], [[8joy]] – hPlk1 Pbd + hpv peptide<br />
*Plk1 Pbd complex with small molecule inhibitor
*Plk1 Pbd complex with small molecule inhibitor
-
**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]], [[8crc]] – hPlk1 + inhibitor<br />
+
**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]], [[8bjt]], [[8crc]] – hPlk1 + inhibitor<br />
**[[2rku]] – hPlk1 (mutant) + inhibitor<br />
**[[2rku]] – hPlk1 (mutant) + inhibitor<br />
**[[3db6]], [[3db8]], [[3dbc]], [[3dbd]], [[3dbe]], [[3dbf]] – zfPlk1 (mutant) + inhibitor – zebra fish<br />
**[[3db6]], [[3db8]], [[3dbc]], [[3dbd]], [[3dbe]], [[3dbf]] – zfPlk1 (mutant) + inhibitor – zebra fish<br />
-
*Plk1 catalytic domain
+
*Plk1 catalytic domain 36-345
**[[2owb]] – hPlk1 catalytic domain (mutant)<br />
**[[2owb]] – hPlk1 catalytic domain (mutant)<br />
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**[[3a7f]], [[3a7g]], [[3a7h]], [[3a7i]], [[3a7j]], [[3ckw]] – hChk24 kinase domain <br />
**[[3a7f]], [[3a7g]], [[3a7h]], [[3a7i]], [[3a7j]], [[3ckw]] – hChk24 kinase domain <br />
-
**[[4w8e]], [[4w8d]], [[4u8z]], [[4qmm]], [[4qmn]], [[4qmo]], [[4qmp]], [[4qmq]], [[4qms]], [[4qmt]], [[4qmu]], [[4qmv]], [[4qmw]], [[4qmx]], [[4qmy]], [[4qmz]], [[4qna]], [[4qo9]], [[4u8z]], [[7b30]], [[7b31]], [[7b32]], [[7b33]], [[7b34]], [[7b35]], [[8bzi]] – hChk Mst3 + inhibitor <br />
+
**[[4w8e]], [[4w8d]], [[4u8z]], [[4qmm]], [[4qmn]], [[4qmo]], [[4qmp]], [[4qmq]], [[4qms]], [[4qmt]], [[4qmu]], [[4qmv]], [[4qmw]], [[4qmx]], [[4qmy]], [[4qmz]], [[4qna]], [[4qo9]], [[4u8z]], [[7b30]], [[7b31]], [[7b32]], [[7b33]], [[7b34]], [[7b35]], [[8bzi]], [[8bzj]], [[8qlr]], [[8qls]], [[8qlt]] – hChk Mst3 + inhibitor <br />
 +
**[[8qlq]] – hChk Mst3 + macrocyclic inhibitor <br /> or STK2
**[[3ckx]] – hChk24 kinase domain + staurosporin <br />
**[[3ckx]] – hChk24 kinase domain + staurosporin <br />
**[[3zhp]] – hChk24 kinase domain + calcium-binding protein <br />
**[[3zhp]] – hChk24 kinase domain + calcium-binding protein <br />
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**[[4qml]] – hChk Mst3 kinase domain + AMPPNP <br />
**[[4qml]] – hChk Mst3 kinase domain + AMPPNP <br />
-
*'''Chk25'''
+
*'''Chk25 or STK25'''
**[[2xik]] – hChk25 kinase domain<br />
**[[2xik]] – hChk25 kinase domain<br />
 +
**[[7z4v]] – hChk25 kinase domain + inhibitor<br />
**[[3w8h]] – hChk25 regulatory domain + programmed cell death protein 10<br />
**[[3w8h]] – hChk25 regulatory domain + programmed cell death protein 10<br />
**[[4nzw]] – hChk25 kinase domain (mutant) + calcium-binding protein <br />
**[[4nzw]] – hChk25 kinase domain (mutant) + calcium-binding protein <br />
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**[[7apj]] - hRac-α hChk + nanobody<br />
**[[7apj]] - hRac-α hChk + nanobody<br />
-
*'''Rac-β hChk'''
+
*'''Rac-β hChk or AKT2'''
**[[1gzk]], [[1gzn]], [[1gzo]], [[1mrv]], [[1mry]] – hRac-β hChk kinase domain<br />
**[[1gzk]], [[1gzn]], [[1gzo]], [[1mrv]], [[1mry]] – hRac-β hChk kinase domain<br />
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**[[3e87]], [[3e88]], [[3e8d]] - Rac-β hChk kinase domain (mutant) + GSK3 peptide + inhibitor<br /
**[[3e87]], [[3e88]], [[3e8d]] - Rac-β hChk kinase domain (mutant) + GSK3 peptide + inhibitor<br /
**[[1o6l]] - hRac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP<br />
**[[1o6l]] - hRac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP<br />
-
**[[3d0e]] - hRac-β hChk kinase domain (mutant) + inhibitor<br />
+
**[[3d0e]], [[8q61]] - hRac-β hChk kinase domain (mutant) + inhibitor<br />
*'''Rac-γ hChk (ATK3)'''
*'''Rac-γ hChk (ATK3)'''
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*'''B-Raf'''; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723
*'''B-Raf'''; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723
-
**[[8dgt]] – hB-Raf in Ras/Raf complex – Cryo EM<br />
+
**[[8dgs]], [[8dgt]] – hB-Raf in Ras/Raf complex – Cryo EM<br />
 +
**[[7zr5]] – hB-Raf + Hsp90 + CDC37 + PP5 – Cryo EM<br />
**[[1uwh]], [[3c4c]], [[6v2u]], [[6xfp]], [[6xlo]], [[8f7o]], [[8f7p]] – hB-Raf kinase domain + anticancer drug<br />
**[[1uwh]], [[3c4c]], [[6v2u]], [[6xfp]], [[6xlo]], [[8f7o]], [[8f7p]] – hB-Raf kinase domain + anticancer drug<br />
**[[1uwj]], [[6p3d]] – hB-Raf kinase domain (mutant) + anticancer drug<br />
**[[1uwj]], [[6p3d]] – hB-Raf kinase domain (mutant) + anticancer drug<br />
-
**[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]] – hB-Raf kinase domain + pyrazole inhibitor<br />
+
**[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]], [[7shv]] – hB-Raf kinase domain + pyrazole inhibitor<br />
**[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]], [[6p7d]], [[6uuo]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br />
**[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]], [[6p7d]], [[6uuo]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br />
-
**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]], [[7k0v]], [[7p3b]], [[7p3v]], [[8c7y]] - hB-Raf kinase domain + inhibitor<br />
+
**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]], [[7k0v]], [[7p3b]], [[7p3v]], [[8c7x]], [[8c7y]] - hB-Raf kinase domain + inhibitor<br />
**[[6v34]] – hB-Raf kinase domain (mutant) + inhibitor<br />
**[[6v34]] – hB-Raf kinase domain (mutant) + inhibitor<br />
**[[4mne]] – hB-Raf kinase domain + MAPKK1<br />
**[[4mne]] – hB-Raf kinase domain + MAPKK1<br />
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**[[7mfd]] – hB-Raf + 14-3-3 ζ/δ + MEK + inhibitor – Cryo EM<br />
**[[7mfd]] – hB-Raf + 14-3-3 ζ/δ + MEK + inhibitor – Cryo EM<br />
**[[6pp9]] – hB-Raf kinase domain + MEK1 + ANP<br />
**[[6pp9]] – hB-Raf kinase domain + MEK1 + ANP<br />
 +
**[[7m0x]], [[7m0z]] – hB-Raf kinase domain + MEK1 + ANP + inhibitor<br />
 +
**[[7m0t]], [[7m0u]], [[7m0v]], [[7m0w]], [[7m0y]] – hB-Raf kinase domain + MEK1 + ANP + drug<br />
**[[6u2g]] – hB-Raf kinase domain + MEK1 + AMPPCP<br />
**[[6u2g]] – hB-Raf kinase domain + MEK1 + AMPPCP<br />
**[[5vr3]] – hB-Raf BRS domain <br />
**[[5vr3]] – hB-Raf BRS domain <br />
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**[[4otd]] - hChk Pak-1 kinase domain<br />
**[[4otd]] - hChk Pak-1 kinase domain<br />
**[[1yhv]], [[1yhw]], [[3q4z]], [[3q52]], [[3q53]] – hChk Pak-1 kinase domain (mutant)<br />
**[[1yhv]], [[1yhw]], [[3q4z]], [[3q52]], [[3q53]] – hChk Pak-1 kinase domain (mutant)<br />
-
**[[4o0r]], [[4o0t]], [[4zji]], [[4zjj]], [[4zlo]], [[4zy4]], [[4zy5]], [[4zy7]], [[5ime]], [[5kbq]], [[5kbr]], [[6b16]] – hChk Pak-1 kinase domain + inhibitor<br />
+
**[[4o0r]], [[4o0t]], [[4zji]], [[4zjj]], [[4zlo]], [[4zy4]], [[4zy5]], [[4zy7]], [[5ime]], [[5kbq]], [[5kbr]], [[6b16]], [[7vto]] – hChk Pak-1 kinase domain + inhibitor<br />
**[[4oti]], [[4oth]], [[4otg]] – hChk Pak-1 kinase domain + inhibitor<br />
**[[4oti]], [[4oth]], [[4otg]] – hChk Pak-1 kinase domain + inhibitor<br />
**[[4eqc]], [[4p90]], [[5dew]], [[5dey]], [[5dfp]] – hChk Pak-1 kinase domain (mutant) + inhibitor<br />
**[[4eqc]], [[4p90]], [[5dew]], [[5dey]], [[5dfp]] – hChk Pak-1 kinase domain (mutant) + inhibitor<br />
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**[[4b9d]] - hChk Nek1 kinase domain (mutant) + inhibitor<br />
**[[4b9d]] - hChk Nek1 kinase domain (mutant) + inhibitor<br />
**[[2w5h]] – hChk Nek2 kinase domain<br />
**[[2w5h]] – hChk Nek2 kinase domain<br />
-
**[[2jav]], [[2wqo]], [[2xk3]], [[2xk4]], [[2xk6]], [[2xk7]], [[2xk8]], [[2xkc]], [[2xkd]], [[2xke]], [[2xkf]], [[2xnm]], [[2xnn]], [[2xno]], [[2xnp]], [[4a4x]], [[4afe]], [[5m51]], [[5m53]], [[5m55]], [[5m57]], [[6sk9]], [[6sgh]], [[6sgi]], [[6sgk]] – hChk Nek2 + inhibitor<br />
+
**[[2jav]], [[2wqo]], [[2xk3]], [[2xk4]], [[2xk6]], [[2xk7]], [[2xk8]], [[2xkc]], [[2xkd]], [[2xke]], [[2xkf]], [[2xnm]], [[2xnn]], [[2xno]], [[2xnp]], [[4a4x]], [[4afe]], [[5m51]], [[5m53]], [[5m55]], [[5m57]], [[6sgd]], [[6sk9]], [[6sgh]], [[6sgi]], [[6sgk]], [[8sk9]] – hChk Nek2 + inhibitor<br />
**[[2w5a]], [[2w5b]] – hChk Nek2 + nucleotide<br />
**[[2w5a]], [[2w5b]] – hChk Nek2 + nucleotide<br />
**[[6tm5]] - hChk Nek2 in anaphase-promoting complex – Cryo EM<br />
**[[6tm5]] - hChk Nek2 in anaphase-promoting complex – Cryo EM<br />
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**[[2lru]] – rChk Wnk1 autoinhibitory domain 480-572 - NMR<br />
**[[2lru]] – rChk Wnk1 autoinhibitory domain 480-572 - NMR<br />
**[[5w7t]] - rChk Wnk1 kinase domain <br />
**[[5w7t]] - rChk Wnk1 kinase domain <br />
 +
**[[7uos]] - rChk Wnk1 kinase domain (mutant)<br />
*'''TANK-binding kinase'''
*'''TANK-binding kinase'''
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**[[6sb0]] – hChk Mtor + RAPTOR + LST8 + RAGA + RAGC + proline-rich Akt1 substrate – Cryo EM <br />
**[[6sb0]] – hChk Mtor + RAPTOR + LST8 + RAGA + RAGC + proline-rich Akt1 substrate – Cryo EM <br />
**[[5zcs]] – hmTOR + LST8 + AVO3 + TORC2 – Cryo EM <br />
**[[5zcs]] – hmTOR + LST8 + AVO3 + TORC2 – Cryo EM <br />
 +
**[[7tzo]] – hTORC2 in mTORC2 complex– Cryo EM <br />
**[[6zwm]], [[6zwo]], [[7owg]], [[7pe7]], [[7pe8]], [[7pe9]], [[7pea]], [[7peb]], [[7pec]], [[7uxc]], [[8era]] – mTOR in mTor complex – Cryo EM <br />
**[[6zwm]], [[6zwo]], [[7owg]], [[7pe7]], [[7pe8]], [[7pe9]], [[7pea]], [[7peb]], [[7pec]], [[7uxc]], [[8era]] – mTOR in mTor complex – Cryo EM <br />
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**[[6ac5]] – hRip1 death domain <br />
**[[6ac5]] – hRip1 death domain <br />
-
**[[6r5f]], [[6nw2]], [[6c4d]], [[6c3e]], [[5tx5]], [[7fcz]], [[7fd0]] – hRip1 catalytic domain + inhibitor <br />
+
**[[6r5f]], [[6nw2]], [[6c4d]], [[6c3e]], [[5tx5]], [[7fcz]], [[7fd0]], [[7ydx]] – hRip1 catalytic domain + inhibitor <br />
**[[6rln]], [[6ocq]], [[6nyh]], [[6hho]] – hRip1 catalytic domain (mutant) + inhibitor <br />
**[[6rln]], [[6ocq]], [[6nyh]], [[6hho]] – hRip1 catalytic domain (mutant) + inhibitor <br />
**[[6ggs]] – hRip2 – Cryo EM <br />
**[[6ggs]] – hRip2 – Cryo EM <br />
Line 623: Line 632:
**[[6szj]], [[6sze]], [[6s1f]], [[6rna]], [[6rn8]], [[6hmx]], [[6fu5]], [[6es0]], [[5w5o]], [[5w5j]] – hRip2 catalytic domain + inhibitor <br />
**[[6szj]], [[6sze]], [[6s1f]], [[6rna]], [[6rn8]], [[6hmx]], [[6fu5]], [[6es0]], [[5w5o]], [[5w5j]] – hRip2 catalytic domain + inhibitor <br />
**[[6ul8]] – hRip2 catalytic domain (mutant) + inhibitor <br />
**[[6ul8]] – hRip2 catalytic domain (mutant) + inhibitor <br />
 +
**[[8aza]] – hRip2 catalytic domain + XiaP Bir2 domain – Cryo EM <br />
**[[7mx3]] – hRip3 catalytic domain (mutant) + inhibitor <br />
**[[7mx3]] – hRip3 catalytic domain (mutant) + inhibitor <br />
**[[7mon]] – hRip3 catalytic domain (mutant) + MLKL <br />
**[[7mon]] – hRip3 catalytic domain (mutant) + MLKL <br />
Line 665: Line 675:
*'''Chk Smg'''
*'''Chk Smg'''
- 
**[[6l53]] – hChk Smg1 – Cryo EM <br />
**[[6l53]] – hChk Smg1 – Cryo EM <br />
Line 679: Line 688:
**[[4um2]] – hChk Smg6 TPR domain <br />
**[[4um2]] – hChk Smg6 TPR domain <br />
**[[1ya0]] – hChk Smg7 N terminal <br />
**[[1ya0]] – hChk Smg7 N terminal <br />
 +
 +
*'''Chk Vprbp or DCAF1'''
 +
 +
**[[4pxw]], [[8ood]] – hChk Vprbp WD repeat domain 1039-1401 (mutant) <br />
 +
**[[7sse]], [[7ufv]], [[8f8e]], [[8og5]], [[8og6]], [[8og7]], [[8og8]], [[8og9]], [[8oga]], [[8ogb]], [[8ogc]], [[8oo5]], [[8ood]] – hChk Vprbp WD repeat domain (mutant) + inhibitor<br />
 +
**[[5aja]] – hChk Vprbp WD repeat domain + VPX + SAMHD1<br />
*'''Other Chk'''
*'''Other Chk'''
Line 686: Line 701:
**[[7okw]] – hChk Osr1 C-terminal <br />
**[[7okw]] – hChk Osr1 C-terminal <br />
**[[4aw2]] – hChk Mrckα kinase domain<br />
**[[4aw2]] – hChk Mrckα kinase domain<br />
-
**[[4pxw]] – hChk Vprbp WD repeat domain (mutant)<br />
+
**[[4pxw]], [[8ood]] – hChk Vprbp WD repeat domain (mutant)<br />
 +
**[[7v7c]] – hChk Vprbp in DDB1-VPRBP-VPR-UNG2 complex – Cryo EM<br />
 +
**[[7v7c]] – hChk Vprbp in DDB1-VPRBP-VPR-UNG2 complex – Cryo EM<br />
**[[1uf0]] – hChk Dcamkl1 DCX domain – NMR<br />
**[[1uf0]] – hChk Dcamkl1 DCX domain – NMR<br />
**[[1u5q]] – rChk Tao2 kinase domain <br />
**[[1u5q]] – rChk Tao2 kinase domain <br />
Line 709: Line 726:
**[[6sl1]], [[6sl0]], [[6skz]], [[6sky]] – Chk Tel1 – ''Chaetonium thermophilum'' – Cryo EM<br />
**[[6sl1]], [[6sl0]], [[6skz]], [[6sky]] – Chk Tel1 – ''Chaetonium thermophilum'' – Cryo EM<br />
**[[6ra0]] – CeChk Dkf1 – ''Chaenorhabditis elegans''<br /><br />
**[[6ra0]] – CeChk Dkf1 – ''Chaenorhabditis elegans''<br /><br />
 +
**[[7z6e]] – CeChk Mrck1 regulatory domain<br />
**[[6tlb]] – Chk – ''Plasmodium falciparum''<br />
**[[6tlb]] – Chk – ''Plasmodium falciparum''<br />
Line 760: Line 778:
*Serine/threonine protein kinase Rad53 see [[Rad53]]
*Serine/threonine protein kinase Rad53 see [[Rad53]]
 +
 +
*Serine/threonine protein kinase Gsk3B see [[Glycogen synthase kinase-3 beta]]
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:19, 19 November 2023

3D structures of serine/threonine protein kinase

Updated on 19-November-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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