From Proteopedia
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| | + | '''Unreleased structure''' |
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| - | ==Crystal structure of Scribble PDZ1 with PTHR==
| + | The entry 8bj0 is ON HOLD until Paper Publication |
| - | <StructureSection load='8bj0' size='340' side='right'caption='[[8bj0]], [[Resolution|resolution]] 2.60Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[8bj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BJ0 FirstGlance]. <br>
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| - | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr>
| + | Description: |
| - | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
| + | [[Category: Unreleased Structures]] |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bj0 OCA], [https://pdbe.org/8bj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bj0 RCSB], [https://www.ebi.ac.uk/pdbsum/8bj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bj0 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
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| - | == Function ==
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| - | [https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]] | + | |
| - | [[Category: Large Structures]]
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| - | [[Category: Kvansakul M]]
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| - | [[Category: Stewart BZ]]
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Current revision
Unreleased structure
The entry 8bj0 is ON HOLD until Paper Publication
Authors:
Description:
