From Proteopedia
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| | + | '''Unreleased structure''' |
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| - | ==Structure of human SGLT2-MAP17 complex with Dapagliflozin==
| + | The entry 8hez is ON HOLD until 2024-11-09 |
| - | <StructureSection load='8hez' size='340' side='right'caption='[[8hez]], [[Resolution|resolution]] 2.80Å' scene=''>
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| - | == Structural highlights ==
| + | Authors: Hiraizumi, M., Kishida, H., Miyaguchi, I., Nureki, O. |
| - | <table><tr><td colspan='2'>[[8hez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HEZ FirstGlance]. <br>
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| - | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr>
| + | Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin |
| - | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LE6:(2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol'>LE6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
| + | [[Category: Unreleased Structures]] |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hez OCA], [https://pdbe.org/8hez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hez RCSB], [https://www.ebi.ac.uk/pdbsum/8hez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hez ProSAT]</span></td></tr>
| + | [[Category: Nureki, O]] |
| - | </table>
| + | [[Category: Kishida, H]] |
| - | == Disease ==
| + | [[Category: Miyaguchi, I]] |
| - | [https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Familial renal glucosuria. The disease is caused by variants affecting the gene represented in this entry.
| + | [[Category: Hiraizumi, M]] |
| - | == Function ==
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| - | [https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).[UniProtKB:Q923I7]<ref>PMID:20980548</ref> <ref>PMID:28592437</ref> <ref>PMID:34880493</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]] | + | |
| - | [[Category: Large Structures]]
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| - | [[Category: Hiraizumi M]] | + | |
| - | [[Category: Kishida H]] | + | |
| - | [[Category: Miyaguchi I]] | + | |
| - | [[Category: Nureki O]] | + | |
Revision as of 05:30, 22 November 2023
Unreleased structure
The entry 8hez is ON HOLD until 2024-11-09
Authors: Hiraizumi, M., Kishida, H., Miyaguchi, I., Nureki, O.
Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin
