From Proteopedia
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| | + | '''Unreleased structure''' |
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| - | ==Structure of human RyR2-S2808D in the closed state in the presence of ARM210==
| + | The entry 8uq3 is ON HOLD until sometime in the future |
| - | <StructureSection load='8uq3' size='340' side='right'caption='[[8uq3]], [[Resolution|resolution]] 3.18Å' scene=''>
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| - | == Structural highlights ==
| + | Authors: Miotto, M.C., Marks, A.R. |
| - | <table><tr><td colspan='2'>[[8uq3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UQ3 FirstGlance]. <br>
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| - | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.18Å</td></tr>
| + | Description: Structure of human RyR2-S2808D in the closed state in the presence of ARM210 |
| - | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=KVR:4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic+acid'>KVR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
| + | [[Category: Unreleased Structures]] |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uq3 OCA], [https://pdbe.org/8uq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uq3 RCSB], [https://www.ebi.ac.uk/pdbsum/8uq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uq3 ProSAT]</span></td></tr>
| + | [[Category: Miotto, M.C]] |
| - | </table>
| + | [[Category: Marks, A.R]] |
| - | == Disease ==
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| - | [https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Catecholaminergic polymorphic ventricular tachycardia;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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| - | == Function ==
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| - | [https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10830164</ref> <ref>PMID:20056922</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]] | + | |
| - | [[Category: Large Structures]] | + | |
| - | [[Category: Marks AR]] | + | |
| - | [[Category: Miotto MC]]
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Revision as of 05:57, 22 November 2023
Unreleased structure
The entry 8uq3 is ON HOLD until sometime in the future
Authors: Miotto, M.C., Marks, A.R.
Description: Structure of human RyR2-S2808D in the closed state in the presence of ARM210
