1oc6

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[[Image:1oc6.jpg|left|200px]]
[[Image:1oc6.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1oc6 |SIZE=350|CAPTION= <scene name='initialview01'>1oc6</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1oc6", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ACI:Gol+Binding+Site+For+Chain+A'>ACI</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1oc6| PDB=1oc6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc6 OCA], [http://www.ebi.ac.uk/pdbsum/1oc6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oc6 RCSB]</span>
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}}
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'''STRUCTURE NATIVE OF THE D405N MUTANT OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS AT 1.5 ANGSTROM RESOLUTION'''
'''STRUCTURE NATIVE OF THE D405N MUTANT OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS AT 1.5 ANGSTROM RESOLUTION'''
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[[Category: Schulein, M.]]
[[Category: Schulein, M.]]
[[Category: Varrot, A.]]
[[Category: Varrot, A.]]
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[[Category: cellobiohydrolase]]
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[[Category: Cellobiohydrolase]]
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[[Category: cellulase]]
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[[Category: Cellulase]]
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[[Category: cellulose degradation]]
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[[Category: Cellulose degradation]]
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[[Category: glycoside hydrolase family 6]]
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[[Category: Glycoside hydrolase family 6]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: processive mechanism]]
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[[Category: Processive mechanism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:39:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:43:04 2008''
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Revision as of 00:39, 3 May 2008

Image:1oc6.jpg

Template:STRUCTURE 1oc6

STRUCTURE NATIVE OF THE D405N MUTANT OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS AT 1.5 ANGSTROM RESOLUTION


Overview

The enzymatic digestion of cellulose entails intimate involvement of cellobiohydrolases, whose characteristic active-center tunnel contributes to a processive degradation of the polysaccharide. The cellobiohydrolase Cel6A displays an active site within a tunnel formed by two extended loops, which are known to open and close in response to ligand binding. Here we present five structures of wild-type and mutant forms of Cel6A from Humicola insolens in complex with nonhydrolyzable thio-oligosaccharides, at resolutions from 1.7-1.1 A, dissecting the structural accommodation of a processing substrate chain through the active center during hydrolysis. Movement of ligand is facilitated by extensive solvent-mediated interactions and through flexibility in the hydrophobic surfaces provided by a sheath of tryptophan residues.

About this Structure

1OC6 is a Single protein structure of sequence from Humicola insolens. Full crystallographic information is available from OCA.

Reference

Structural basis for ligand binding and processivity in cellobiohydrolase Cel6A from Humicola insolens., Varrot A, Frandsen TP, von Ossowski I, Boyer V, Cottaz S, Driguez H, Schulein M, Davies GJ, Structure. 2003 Jul;11(7):855-64. PMID:12842048 Page seeded by OCA on Sat May 3 03:39:25 2008

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OCA

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