8u36
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of the classical binding interface of Importin alpha 2 and a nuclear localisation signal sequence in Frog siadenovirus core protein VII== |
| - | + | <StructureSection load='8u36' size='340' side='right'caption='[[8u36]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8u36]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Frog_siadenovirus_A Frog siadenovirus A] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U36 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u36 OCA], [https://pdbe.org/8u36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u36 RCSB], [https://www.ebi.ac.uk/pdbsum/8u36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u36 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Athukorala | + | == Function == |
| - | [[Category: Donnelly | + | [https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Frog siadenovirus A]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Athukorala A]] | ||
| + | [[Category: Donnelly CM]] | ||
| + | [[Category: Forwood JK]] | ||
| + | [[Category: Sarker S]] | ||
Revision as of 07:34, 22 November 2023
The crystal structure of the classical binding interface of Importin alpha 2 and a nuclear localisation signal sequence in Frog siadenovirus core protein VII
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