8uxi

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m (Protected "8uxi" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8uxi is ON HOLD
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==Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium==
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<StructureSection load='8uxi' size='340' side='right'caption='[[8uxi]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
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Authors: Miotto, M.C., Marks, A.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8uxi]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UXI FirstGlance]. <br>
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Description: Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Miotto, M.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uxi OCA], [https://pdbe.org/8uxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uxi RCSB], [https://www.ebi.ac.uk/pdbsum/8uxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uxi ProSAT]</span></td></tr>
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[[Category: Marks, A.R]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Catecholaminergic polymorphic ventricular tachycardia;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10830164</ref> <ref>PMID:20056922</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Marks AR]]
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[[Category: Miotto MC]]

Revision as of 07:35, 22 November 2023

Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium

PDB ID 8uxi

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