8uxl

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m (Protected "8uxl" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8uxl is ON HOLD
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==Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin==
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<StructureSection load='8uxl' size='340' side='right'caption='[[8uxl]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
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Authors: Miotto, M.C., Marks, A.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8uxl]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UXL FirstGlance]. <br>
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Description: Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.12&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Miotto, M.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uxl OCA], [https://pdbe.org/8uxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uxl RCSB], [https://www.ebi.ac.uk/pdbsum/8uxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uxl ProSAT]</span></td></tr>
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[[Category: Marks, A.R]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Catecholaminergic polymorphic ventricular tachycardia;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10830164</ref> <ref>PMID:20056922</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Marks AR]]
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[[Category: Miotto MC]]

Revision as of 07:35, 22 November 2023

Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin

PDB ID 8uxl

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