8uxm

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m (Protected "8uxm" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8uxm is ON HOLD
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==Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin==
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<StructureSection load='8uxm' size='340' side='right'caption='[[8uxm]], [[Resolution|resolution]] 3.56&Aring;' scene=''>
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Authors: Miotto, M.C., Marks, A.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8uxm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UXM FirstGlance]. <br>
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Description: Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.56&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Miotto, M.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uxm OCA], [https://pdbe.org/8uxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uxm RCSB], [https://www.ebi.ac.uk/pdbsum/8uxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uxm ProSAT]</span></td></tr>
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[[Category: Marks, A.R]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Marks AR]]
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[[Category: Miotto MC]]

Revision as of 07:35, 22 November 2023

Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin

PDB ID 8uxm

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