8wjy

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'''Unreleased structure'''
 
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The entry 8wjy is ON HOLD until 2024-11-21
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==PKMYT1_Cocrystal_Cpd 4==
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<StructureSection load='8wjy' size='340' side='right'caption='[[8wjy]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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Authors: Wang, Y., Wang, C., Liu, T., Qi, H., Chen, S., Cai, X., Zhang, M., Aliper, A., Ren, F., Ding, X., Zhavoronkov, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8wjy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WJY FirstGlance]. <br>
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Description: PKMYT1_Cocrystal_Cpd 4
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=W9X:[6-azanyl-5-(2,6-dimethyl-3-oxidanyl-phenyl)-2,3-dimethyl-pyrrolo[2,3-b]pyrazin-7-yl]-(6,7-dihydro-4~{H}-pyrazolo[1,5-a]pyrazin-5-yl)methanone'>W9X</scene></td></tr>
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[[Category: Zhang, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wjy OCA], [https://pdbe.org/8wjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wjy RCSB], [https://www.ebi.ac.uk/pdbsum/8wjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wjy ProSAT]</span></td></tr>
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[[Category: Wang, C]]
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</table>
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[[Category: Ren, F]]
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== Function ==
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[[Category: Chen, S]]
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[https://www.uniprot.org/uniprot/PMYT1_HUMAN PMYT1_HUMAN] Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.<ref>PMID:9001210</ref> <ref>PMID:10373560</ref>
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[[Category: Zhavoronkov, A]]
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== References ==
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[[Category: Wang, Y]]
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<references/>
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[[Category: Ding, X]]
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__TOC__
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[[Category: Cai, X]]
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</StructureSection>
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[[Category: Aliper, A]]
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[[Category: Homo sapiens]]
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[[Category: Qi, H]]
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[[Category: Large Structures]]
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[[Category: Liu, T]]
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[[Category: Aliper A]]
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[[Category: Cai X]]
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[[Category: Chen S]]
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[[Category: Ding X]]
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[[Category: Liu T]]
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[[Category: Qi H]]
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[[Category: Ren F]]
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[[Category: Wang C]]
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[[Category: Wang Y]]
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[[Category: Zhang M]]
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[[Category: Zhavoronkov A]]

Revision as of 07:36, 22 November 2023

PKMYT1_Cocrystal_Cpd 4

PDB ID 8wjy

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