1ocn

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[[Image:1ocn.jpg|left|200px]]
[[Image:1ocn.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ocn |SIZE=350|CAPTION= <scene name='initialview01'>1ocn</scene>, resolution 1.31&Aring;
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The line below this paragraph, containing "STRUCTURE_1ocn", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ACI:Ca+Binding+Site+For+Chain+A'>ACI</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IFM:5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE'>IFM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ocn| PDB=1ocn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ocn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ocn OCA], [http://www.ebi.ac.uk/pdbsum/1ocn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ocn RCSB]</span>
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}}
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'''MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION'''
'''MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION'''
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[[Category: Stick, R V.]]
[[Category: Stick, R V.]]
[[Category: Varrot, A.]]
[[Category: Varrot, A.]]
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[[Category: cellobiohydrolase]]
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[[Category: Cellobiohydrolase]]
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[[Category: cellulase]]
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[[Category: Cellulase]]
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[[Category: cellulose degradation]]
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[[Category: Cellulose degradation]]
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[[Category: glycoside hydrolase family 6]]
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[[Category: Glycoside hydrolase family 6]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:40:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:43:19 2008''
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Revision as of 00:40, 3 May 2008

Image:1ocn.jpg

Template:STRUCTURE 1ocn

MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION


Overview

A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.

About this Structure

1OCN is a Single protein structure of sequence from Humicola insolens. Full crystallographic information is available from OCA.

Reference

Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases., Varrot A, Macdonald J, Stick RV, Pell G, Gilbert HJ, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):946-7. PMID:12744312 Page seeded by OCA on Sat May 3 03:40:13 2008

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OCA

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