1oct

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[[Image:1oct.gif|left|200px]]
[[Image:1oct.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1oct", creates the "Structure Box" on the page.
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{{STRUCTURE_1oct| PDB=1oct | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oct OCA], [http://www.ebi.ac.uk/pdbsum/1oct PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oct RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES'''
'''CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES'''
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[[Category: Pabo, C O.]]
[[Category: Pabo, C O.]]
[[Category: Rould, M A.]]
[[Category: Rould, M A.]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:40:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:43:18 2008''
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Revision as of 00:40, 3 May 2008

Image:1oct.gif

Template:STRUCTURE 1oct

CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES


Overview

The structure of an Oct-1 POU domain-octamer DNA complex has been solved at 3.0 A resolution. The POU-specific domain contacts the 5' half of this site (ATGCAAAT), and as predicted from nuclear magnetic resonance studies, the structure, docking, and contacts are remarkably similar to those of the lambda and 434 repressors. The POU homeodomain contacts the 3' half of this site (ATGCAAAT), and the docking is similar to that of the engrailed, MAT alpha 2, and Antennapedia homeodomains. The linker region is not visible and there are no protein-protein contacts between the domains, but overlapping phosphate contacts near the center of the octamer site may favor cooperative binding. This novel arrangement raises important questions about cooperativity in protein-DNA recognition.

About this Structure

1OCT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules., Klemm JD, Rould MA, Aurora R, Herr W, Pabo CO, Cell. 1994 Apr 8;77(1):21-32. PMID:8156594 Page seeded by OCA on Sat May 3 03:40:36 2008

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