5xz5

Structural highlights

Function

ERG10_YEAST Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:7989303, PubMed:5571829). ERG10 catalyzes the formation of acetoacetyl-CoA from acetyl-CoA (PubMed:7989303, PubMed:5571829). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication (PubMed:32679672).^{[1] [2] [3]}

See Also

• Thiolase 3D structures

References

1. ↑ Kornblatt JA, Rudney H. Two forms of acetoacetyl coenzyme A thiolase in yeast. I. Separation and properties. J Biol Chem. 1971 Jul 25;246(14):4417-23 PMID:5571829
2. ↑ Hiser L, Basson ME, Rine J. ERG10 from Saccharomyces cerevisiae encodes acetoacetyl-CoA thiolase. J Biol Chem. 1994 Dec 16;269(50):31383-9 PMID:7989303
3. ↑ Jordá T, Puig S. Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae. Genes (Basel). 2020 Jul 15;11(7):795. PMID:32679672 doi:10.3390/genes11070795