1od8

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[[Image:1od8.jpg|left|200px]]
[[Image:1od8.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1od8 |SIZE=350|CAPTION= <scene name='initialview01'>1od8</scene>, resolution 1.05&Aring;
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The line below this paragraph, containing "STRUCTURE_1od8", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Xys+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XDL:XYLOSE-DERIVED+ISOFAGOMINE+LACTAM'>XDL</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1od8| PDB=1od8 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od8 OCA], [http://www.ebi.ac.uk/pdbsum/1od8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1od8 RCSB]</span>
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}}
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'''XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM'''
'''XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM'''
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[[Category: Gloster, T M.]]
[[Category: Gloster, T M.]]
[[Category: Roberts, S.]]
[[Category: Roberts, S.]]
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[[Category: glycoside hydrolase family 10]]
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[[Category: Glycoside hydrolase family 10]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: isofagomine lactam]]
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[[Category: Isofagomine lactam]]
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[[Category: lectin]]
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[[Category: Lectin]]
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[[Category: transition state mimic]]
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[[Category: Transition state mimic]]
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[[Category: xylan degradation]]
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[[Category: Xylan degradation]]
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[[Category: xylanase]]
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[[Category: Xylanase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:41:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:43:32 2008''
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Revision as of 00:41, 3 May 2008

Image:1od8.jpg

Template:STRUCTURE 1od8

XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM


Overview

The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with "reversed" protonation-states for nucleophile and acid-base.

About this Structure

1OD8 is a Single protein structure of sequence from Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer., Gloster T, Williams SJ, Tarling CA, Roberts S, Dupont C, Jodoin P, Shareck F, Withers SG, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):944-5. PMID:12744311 Page seeded by OCA on Sat May 3 03:41:38 2008

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OCA

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