5y6k

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Current revision (08:23, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5y6k' size='340' side='right'caption='[[5y6k]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
<StructureSection load='5y6k' size='340' side='right'caption='[[5y6k]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5y6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y6K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Y6K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5y6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y6K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8R6:(2S)-6-[2-(7-azido-4-methyl-2-oxidanylidene-chromen-3-yl)ethanoylamino]-2-[bis(2-hydroxy-2-oxoethyl)amino]hexanoic+acid'>8R6</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5y6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y6k OCA], [http://pdbe.org/5y6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y6k RCSB], [http://www.ebi.ac.uk/pdbsum/5y6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y6k ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8R6:(2S)-6-[2-(7-azido-4-methyl-2-oxidanylidene-chromen-3-yl)ethanoylamino]-2-[bis(2-hydroxy-2-oxoethyl)amino]hexanoic+acid'>8R6</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y6k OCA], [https://pdbe.org/5y6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y6k RCSB], [https://www.ebi.ac.uk/pdbsum/5y6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y6k ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chan, G C.F]]
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[[Category: Chan GCF]]
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[[Category: Cheng, T]]
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[[Category: Cheng T]]
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[[Category: Jiang, N]]
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[[Category: Jiang N]]
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[[Category: Jin, L]]
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[[Category: Jin L]]
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[[Category: Li, H]]
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[[Category: Li H]]
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[[Category: Sun, H]]
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[[Category: Sun H]]
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[[Category: Wang, M]]
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[[Category: Wang M]]
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[[Category: Fluorescent]]
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[[Category: Metal transport]]
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[[Category: Probe]]
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[[Category: Transferrin]]
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Current revision

Human serum trnasferrin bound to a fluorescent probe

PDB ID 5y6k

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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