5ygx

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Current revision (08:29, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5ygx' size='340' side='right'caption='[[5ygx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5ygx' size='340' side='right'caption='[[5ygx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ygx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YGX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ygx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YGX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0B5:~{N}-[3-[(4~{R},5~{R},6~{S})-2-azanyl-6-[1,1-bis(fluoranyl)ethyl]-5-fluoranyl-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoranyl-phenyl]-5-(fluoranylmethoxy)pyrazine-2-carboxamide'>0B5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0B5:~{N}-[3-[(4~{R},5~{R},6~{S})-2-azanyl-6-[1,1-bis(fluoranyl)ethyl]-5-fluoranyl-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoranyl-phenyl]-5-(fluoranylmethoxy)pyrazine-2-carboxamide'>0B5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ygx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ygx OCA], [http://pdbe.org/5ygx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ygx RCSB], [http://www.ebi.ac.uk/pdbsum/5ygx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ygx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ygx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ygx OCA], [https://pdbe.org/5ygx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ygx RCSB], [https://www.ebi.ac.uk/pdbsum/5ygx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ygx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Memapsin 2]]
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[[Category: Ando S]]
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[[Category: Ando, S]]
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[[Category: Asada N]]
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[[Category: Asada, N]]
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[[Category: Borghys H]]
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[[Category: Borghys, H]]
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[[Category: Dhuyvetter D]]
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[[Category: Dhuyvetter, D]]
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[[Category: Fuchino K]]
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[[Category: Fuchino, K]]
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[[Category: Fukushima T]]
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[[Category: Fukushima, T]]
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[[Category: Gijsen H]]
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[[Category: Gijsen, H]]
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[[Category: Hasegawa T]]
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[[Category: Hasegawa, T]]
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[[Category: Hosono M]]
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[[Category: Hosono, M]]
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[[Category: Iso Y]]
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[[Category: Iso, Y]]
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[[Category: Kido Y]]
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[[Category: Kido, Y]]
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[[Category: Komano K]]
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[[Category: Komano, K]]
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[[Category: Kusakabe K]]
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[[Category: Kusakabe, K]]
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[[Category: Nakahara K]]
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[[Category: Nakahara, K]]
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[[Category: Ogawa M]]
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[[Category: Ogawa, M]]
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[[Category: Ohnishi S]]
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[[Category: Ohnishi, S]]
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[[Category: Sakaguchi G]]
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[[Category: Sakaguchi, G]]
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[[Category: Sako Y]]
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[[Category: Sako, Y]]
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[[Category: Tadano G]]
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[[Category: Tadano, G]]
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[[Category: Unemura C]]
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[[Category: Unemura, C]]
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[[Category: Yamamoto T]]
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[[Category: Yamamoto, T]]
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[[Category: Yamano Y]]
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[[Category: Yamano, Y]]
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[[Category: Beta secretase]]
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[[Category: Hydrolase-inhibitor complex]]
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Current revision

Structure of BACE1 in complex with N-(3-((4R,5R,6S)-2-amino-6-(1,1-difluoroethyl)-5-fluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide

PDB ID 5ygx

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