5ygx
From Proteopedia
(Difference between revisions)
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<StructureSection load='5ygx' size='340' side='right'caption='[[5ygx]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='5ygx' size='340' side='right'caption='[[5ygx]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[5ygx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGX OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5ygx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YGX FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0B5:~{N}-[3-[(4~{R},5~{R},6~{S})-2-azanyl-6-[1,1-bis(fluoranyl)ethyl]-5-fluoranyl-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoranyl-phenyl]-5-(fluoranylmethoxy)pyrazine-2-carboxamide'>0B5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0B5:~{N}-[3-[(4~{R},5~{R},6~{S})-2-azanyl-6-[1,1-bis(fluoranyl)ethyl]-5-fluoranyl-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoranyl-phenyl]-5-(fluoranylmethoxy)pyrazine-2-carboxamide'>0B5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ygx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ygx OCA], [https://pdbe.org/5ygx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ygx RCSB], [https://www.ebi.ac.uk/pdbsum/5ygx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ygx ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
+ | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | + | [[Category: Ando S]] | |
- | [[Category: Ando | + | [[Category: Asada N]] |
- | [[Category: Asada | + | [[Category: Borghys H]] |
- | [[Category: Borghys | + | [[Category: Dhuyvetter D]] |
- | [[Category: Dhuyvetter | + | [[Category: Fuchino K]] |
- | [[Category: Fuchino | + | [[Category: Fukushima T]] |
- | [[Category: Fukushima | + | [[Category: Gijsen H]] |
- | [[Category: Gijsen | + | [[Category: Hasegawa T]] |
- | [[Category: Hasegawa | + | [[Category: Hosono M]] |
- | [[Category: Hosono | + | [[Category: Iso Y]] |
- | [[Category: Iso | + | [[Category: Kido Y]] |
- | [[Category: Kido | + | [[Category: Komano K]] |
- | [[Category: Komano | + | [[Category: Kusakabe K]] |
- | [[Category: Kusakabe | + | [[Category: Nakahara K]] |
- | [[Category: Nakahara | + | [[Category: Ogawa M]] |
- | [[Category: Ogawa | + | [[Category: Ohnishi S]] |
- | [[Category: Ohnishi | + | [[Category: Sakaguchi G]] |
- | [[Category: Sakaguchi | + | [[Category: Sako Y]] |
- | [[Category: Sako | + | [[Category: Tadano G]] |
- | [[Category: Tadano | + | [[Category: Unemura C]] |
- | [[Category: Unemura | + | [[Category: Yamamoto T]] |
- | [[Category: Yamamoto | + | [[Category: Yamano Y]] |
- | [[Category: Yamano | + | |
- | + | ||
- | + |
Current revision
Structure of BACE1 in complex with N-(3-((4R,5R,6S)-2-amino-6-(1,1-difluoroethyl)-5-fluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
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Categories: Homo sapiens | Large Structures | Ando S | Asada N | Borghys H | Dhuyvetter D | Fuchino K | Fukushima T | Gijsen H | Hasegawa T | Hosono M | Iso Y | Kido Y | Komano K | Kusakabe K | Nakahara K | Ogawa M | Ohnishi S | Sakaguchi G | Sako Y | Tadano G | Unemura C | Yamamoto T | Yamano Y