5yp6

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Current revision (08:34, 22 November 2023) (edit) (undo)
 
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==RORgamma (263-509) complexed with SRC2 and Compound 6==
==RORgamma (263-509) complexed with SRC2 and Compound 6==
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<StructureSection load='5yp6' size='340' side='right' caption='[[5yp6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5yp6' size='340' side='right'caption='[[5yp6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5yp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YP6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5yp6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YP6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CX:N-[3-cyano-4-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide'>4CX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RORC, NR1F3, RORG, RZRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4CX:N-[3-cyano-4-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide'>4CX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yp6 OCA], [http://pdbe.org/5yp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yp6 RCSB], [http://www.ebi.ac.uk/pdbsum/5yp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yp6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yp6 OCA], [https://pdbe.org/5yp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yp6 RCSB], [https://www.ebi.ac.uk/pdbsum/5yp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yp6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cai, W]]
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[[Category: Large Structures]]
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[[Category: Gao, M]]
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[[Category: Cai W]]
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[[Category: Complex structure]]
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[[Category: Gao M]]
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[[Category: Nuclear receptor ror]]
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[[Category: Transcription factor]]
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[[Category: Transcription-inhibitor complex]]
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Current revision

RORgamma (263-509) complexed with SRC2 and Compound 6

PDB ID 5yp6

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