5z2q

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Current revision (08:44, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5z2q' size='340' side='right'caption='[[5z2q]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
<StructureSection load='5z2q' size='340' side='right'caption='[[5z2q]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5z2q]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4eaz 4eaz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z2Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Z2Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5z2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4eaz 4eaz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z2Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5z2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z2q OCA], [http://pdbe.org/5z2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z2q RCSB], [http://www.ebi.ac.uk/pdbsum/5z2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z2q ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z2q OCA], [https://pdbe.org/5z2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z2q RCSB], [https://www.ebi.ac.uk/pdbsum/5z2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z2q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TEAD4_MOUSE TEAD4_MOUSE]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle. [[http://www.uniprot.org/uniprot/VGLL1_MOUSE VGLL1_MOUSE]] May act as a specific coactivator for the mammalian TEFs (By similarity).
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[https://www.uniprot.org/uniprot/VGLL1_MOUSE VGLL1_MOUSE] May act as a specific coactivator for the mammalian TEFs (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pobbati, A V]]
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[[Category: Mus musculus]]
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[[Category: Song, H]]
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[[Category: Pobbati AV]]
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[[Category: Co-regulator]]
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[[Category: Song H]]
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[[Category: Tead]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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[[Category: Vestigial]]
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[[Category: Vgll1]]
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Current revision

Vgll1-TEAD4 core complex

PDB ID 5z2q

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OCA

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