5z8y

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==Crystal structure of human LRRTM2 in complex with Neurexin 1beta==
==Crystal structure of human LRRTM2 in complex with Neurexin 1beta==
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<StructureSection load='5z8y' size='340' side='right' caption='[[5z8y]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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<StructureSection load='5z8y' size='340' side='right'caption='[[5z8y]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5z8y]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z8Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5z8y]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z8Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LRRTM2, KIAA0416, LRRN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NRXN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8y OCA], [http://pdbe.org/5z8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z8y RCSB], [http://www.ebi.ac.uk/pdbsum/5z8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8y OCA], [https://pdbe.org/5z8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z8y RCSB], [https://www.ebi.ac.uk/pdbsum/5z8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8y ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/NRX1B_HUMAN NRX1B_HUMAN]] Pitt-Hopkins-like syndrome;Autism;Schizophrenia.
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[https://www.uniprot.org/uniprot/NRX1B_HUMAN NRX1B_HUMAN] Pitt-Hopkins-like syndrome;Autism;Schizophrenia.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LRRT2_HUMAN LRRT2_HUMAN]] Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). [[http://www.uniprot.org/uniprot/NRX1B_HUMAN NRX1B_HUMAN]] Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).
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[https://www.uniprot.org/uniprot/NRX1B_HUMAN NRX1B_HUMAN] Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5z8y" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5z8y" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Neurexin|Neurexin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Fukai, S]]
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[[Category: Large Structures]]
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[[Category: Yamagata, A]]
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[[Category: Fukai S]]
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[[Category: Cell adhesion]]
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[[Category: Yamagata A]]
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[[Category: Leucine-rich repeat]]
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[[Category: Synapse]]
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[[Category: Synaptic organizer]]
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Revision as of 08:50, 22 November 2023

Crystal structure of human LRRTM2 in complex with Neurexin 1beta

PDB ID 5z8y

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