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5zef

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Current revision (08:52, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5zef' size='340' side='right'caption='[[5zef]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='5zef' size='340' side='right'caption='[[5zef]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zef]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enthi Enthi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZEF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zef]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZEF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NVA:NORVALINE'>NVA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EHI_152330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5759 ENTHI])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NVA:NORVALINE'>NVA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zef OCA], [https://pdbe.org/5zef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zef RCSB], [https://www.ebi.ac.uk/pdbsum/5zef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zef ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zef OCA], [http://pdbe.org/5zef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zef RCSB], [http://www.ebi.ac.uk/pdbsum/5zef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zef ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARGI_ENTH1 ARGI_ENTH1] Catalyzes the hydrolysis of L-arginine into urea and L-ornithine, which is a precursor for polyamine biosynthesis (PubMed:15053781, PubMed:29691540, PubMed:31199070). By depleting host L-arginine, a substrate for nitric oxide synthase (NOS), prevents the production of nitric oxide (NO) by host activated macrophages, and thus allows the parasite to evade host immune response (PubMed:15053781).<ref>PMID:15053781</ref> <ref>PMID:29691540</ref> <ref>PMID:31199070</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5zef" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5zef" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Arginase 3D structures|Arginase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arginase]]
 
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[[Category: Enthi]]
 
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[[Category: Large Structures]]
 
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[[Category: Ankri, S]]
 
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[[Category: Dalal, V]]
 
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[[Category: Malik, A]]
 
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[[Category: Tomar, S]]
 
[[Category: Entamoeba histolytica]]
[[Category: Entamoeba histolytica]]
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[[Category: Hydrolase]]
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[[Category: Large Structures]]
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[[Category: Inhibition]]
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[[Category: Ankri S]]
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[[Category: Metalloenzyme]]
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[[Category: Dalal V]]
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[[Category: Malik A]]
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[[Category: Tomar S]]

Current revision

Crystal structure of Entamoeba histolytica Arginase in complex with L- Norvaline at 2.01 A

PDB ID 5zef

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