5zka

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Current revision (08:58, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5zka' size='340' side='right'caption='[[5zka]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
<StructureSection load='5zka' size='340' side='right'caption='[[5zka]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zka]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZKA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zka]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusobacterium_nucleatum_subsp._nucleatum_ATCC_25586 Fusobacterium nucleatum subsp. nucleatum ATCC 25586]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZKA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zka OCA], [https://pdbe.org/5zka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zka RCSB], [https://www.ebi.ac.uk/pdbsum/5zka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zka ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zka OCA], [http://pdbe.org/5zka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zka RCSB], [http://www.ebi.ac.uk/pdbsum/5zka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zka ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NANA_FUSNN NANA_FUSNN]] Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
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[https://www.uniprot.org/uniprot/NANA_FUSNN NANA_FUSNN] Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5zka" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5zka" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[N-acetylneuraminate lyase|N-acetylneuraminate lyase]]
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*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fusobacterium nucleatum subsp. nucleatum ATCC 25586]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: N-acetylneuraminate lyase]]
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[[Category: Kumar JP]]
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[[Category: Kumar, J P]]
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[[Category: Nayak V]]
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[[Category: Nayak, V]]
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[[Category: Ramaswamy S]]
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[[Category: Ramaswamy, S]]
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[[Category: Rao H]]
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[[Category: Rao, H]]
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[[Category: Lyase]]
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[[Category: Schiff base]]
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[[Category: Sialic acid catabolism]]
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[[Category: Tim-barrel]]
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Current revision

Crystal structure of N-acetylneuraminate lyase from Fusobacterium nucleatum complexed with Pyruvate

PDB ID 5zka

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OCA

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