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5zkp

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Current revision (08:59, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5zkp' size='340' side='right'caption='[[5zkp]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
<StructureSection load='5zkp' size='340' side='right'caption='[[5zkp]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zkp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZKP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zkp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._Hildenborough Desulfovibrio vulgaris str. Hildenborough] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZKP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9ER:N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine'>9ER</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zkp OCA], [http://pdbe.org/5zkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zkp RCSB], [http://www.ebi.ac.uk/pdbsum/5zkp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zkp ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9ER:N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine'>9ER</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zkp OCA], [https://pdbe.org/5zkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zkp RCSB], [https://www.ebi.ac.uk/pdbsum/5zkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zkp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTAFR_HUMAN PTAFR_HUMAN]] Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.<ref>PMID:1281995</ref> <ref>PMID:1374385</ref> <ref>PMID:1656963</ref> <ref>PMID:1657923</ref>
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[https://www.uniprot.org/uniprot/PTAFR_HUMAN PTAFR_HUMAN] Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.<ref>PMID:1281995</ref> <ref>PMID:1374385</ref> <ref>PMID:1656963</ref> <ref>PMID:1657923</ref> [https://www.uniprot.org/uniprot/FLAV_DESVH FLAV_DESVH] Low-potential electron donor to a number of redox enzymes.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Desulfovibrio vulgaris str. Hildenborough]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cao, C]]
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[[Category: Cao C]]
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[[Category: Wu, B]]
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[[Category: Wu B]]
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[[Category: Zhang, X C]]
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[[Category: Zhang XC]]
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[[Category: Zhao, Q]]
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[[Category: Zhao Q]]
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[[Category: Complex]]
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[[Category: G protein-coupled receptor]]
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[[Category: Platelet-activating factor receptor]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the human platelet-activating factor receptor in complex with SR 27417

PDB ID 5zkp

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