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5zm6

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Current revision (09:00, 22 November 2023) (edit) (undo)
 
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==Crystal structure of ORP1-ORD in complex with PI(4,5)P2==
==Crystal structure of ORP1-ORD in complex with PI(4,5)P2==
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<StructureSection load='5zm6' size='340' side='right' caption='[[5zm6]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='5zm6' size='340' side='right'caption='[[5zm6]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zm6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZM6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zm6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZM6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IEP:[(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl]+icosa-5,8,11,14-tetraenoate'>IEP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IEP:[(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl]+icosa-5,8,11,14-tetraenoate'>IEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zm6 OCA], [http://pdbe.org/5zm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zm6 RCSB], [http://www.ebi.ac.uk/pdbsum/5zm6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zm6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zm6 OCA], [https://pdbe.org/5zm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zm6 RCSB], [https://www.ebi.ac.uk/pdbsum/5zm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zm6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OSBL1_HUMAN OSBL1_HUMAN]] Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).<ref>PMID:16176980</ref> <ref>PMID:17428193</ref>
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[https://www.uniprot.org/uniprot/OSBL1_HUMAN OSBL1_HUMAN] Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).<ref>PMID:16176980</ref> <ref>PMID:17428193</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Dong, J]]
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[[Category: Large Structures]]
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[[Category: Luo, Z]]
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[[Category: Dong J]]
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[[Category: Wang, J]]
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[[Category: Luo Z]]
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[[Category: Wu, J W]]
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[[Category: Wang J]]
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[[Category: Complex]]
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[[Category: Wu JW]]
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[[Category: Lipid transport]]
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[[Category: Phospholipid]]
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[[Category: Transporter]]
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Current revision

Crystal structure of ORP1-ORD in complex with PI(4,5)P2

PDB ID 5zm6

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