6ajj

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==Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with ICA38==
==Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with ICA38==
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<StructureSection load='6ajj' size='340' side='right' caption='[[6ajj]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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<StructureSection load='6ajj' size='340' side='right'caption='[[6ajj]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ajj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AJJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ajj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AJJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J9E:4,6-difluoro-N-(spiro[5.5]undecan-3-yl)-1H-indole-2-carboxamide'>J9E</scene>, <scene name='pdbligand=L6T:alpha-D-glucopyranosyl+6-O-dodecyl-alpha-D-glucopyranoside'>L6T</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.794&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">e, T4Tp126 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J9E:4,6-difluoro-N-(spiro[5.5]undecan-3-yl)-1H-indole-2-carboxamide'>J9E</scene>, <scene name='pdbligand=L6T:alpha-D-glucopyranosyl+6-O-dodecyl-alpha-D-glucopyranoside'>L6T</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ajj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ajj OCA], [https://pdbe.org/6ajj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ajj RCSB], [https://www.ebi.ac.uk/pdbsum/6ajj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ajj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ajj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ajj OCA], [http://pdbe.org/6ajj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ajj RCSB], [http://www.ebi.ac.uk/pdbsum/6ajj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ajj ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D9IEF7_BPT4 D9IEF7_BPT4] [https://www.uniprot.org/uniprot/MMPL3_MYCS2 MMPL3_MYCS2] Transports trehalose monomycolate (TMM) to the cell wall (PubMed:31239378, PubMed:22520756, PubMed:28698380). Flips TMM across the inner membrane. Membrane potential is not required for this function (PubMed:28698380). Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) (PubMed:31113875). Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness (PubMed:28703701).<ref>PMID:22520756</ref> <ref>PMID:28698380</ref> <ref>PMID:28703701</ref> <ref>PMID:31113875</ref> <ref>PMID:31239378</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bpt4]]
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[[Category: Escherichia virus T4]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Li, J]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Rao, Z H]]
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[[Category: Li J]]
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[[Category: Wu, L J]]
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[[Category: Rao ZH]]
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[[Category: Yang, H T]]
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[[Category: Wu LJ]]
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[[Category: Yang, X L]]
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[[Category: Yang HT]]
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[[Category: Zhang, B]]
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[[Category: Yang XL]]
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[[Category: Cell wall biosynthesis]]
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[[Category: Zhang B]]
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[[Category: Drug target]]
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[[Category: Hydrolase]]
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[[Category: Membrane protein]]
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[[Category: Rnd family]]
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[[Category: Transporter]]
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Current revision

Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with ICA38

PDB ID 6ajj

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OCA

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