6iiu

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==Crystal structure of the human thromboxane A2 receptor bound to ramatroban==
==Crystal structure of the human thromboxane A2 receptor bound to ramatroban==
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<StructureSection load='6iiu' size='340' side='right' caption='[[6iiu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='6iiu' size='340' side='right'caption='[[6iiu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6iiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IIU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6iiu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum], [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IIU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8X:3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic+acid'>A8X</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TBXA2R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8X:3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic+acid'>A8X</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iiu OCA], [http://pdbe.org/6iiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iiu RCSB], [http://www.ebi.ac.uk/pdbsum/6iiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iiu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iiu OCA], [https://pdbe.org/6iiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iiu RCSB], [https://www.ebi.ac.uk/pdbsum/6iiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iiu ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TA2R_HUMAN TA2R_HUMAN] Bleeding diathesis due to thromboxane synthesis deficiency. Disease susceptibility is associated with variants affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/TA2R_HUMAN TA2R_HUMAN] Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.<ref>PMID:8613548</ref> Activates adenylyl cyclase.<ref>PMID:8613548</ref> Inhibits adenylyl cyclase.<ref>PMID:8613548</ref> [https://www.uniprot.org/uniprot/RUBR_CLOPA RUBR_CLOPA] Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Clostridium pasteurianum]]
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[[Category: Fan, H]]
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[[Category: Escherichia coli]]
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[[Category: Wu, B]]
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[[Category: Homo sapiens]]
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[[Category: Zhao, Q]]
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[[Category: Large Structures]]
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[[Category: Antagonist]]
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[[Category: Fan H]]
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[[Category: Complex]]
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[[Category: Wu B]]
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[[Category: Gpcr]]
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[[Category: Zhao Q]]
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[[Category: Signaling protein]]
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Revision as of 09:43, 22 November 2023

Crystal structure of the human thromboxane A2 receptor bound to ramatroban

PDB ID 6iiu

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