6ivx

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Current revision (09:53, 22 November 2023) (edit) (undo)
 
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<StructureSection load='6ivx' size='340' side='right'caption='[[6ivx]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='6ivx' size='340' side='right'caption='[[6ivx]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ivx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IVX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ivx]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AYO:(4S)-4-[4-cyclopropyl-5-(2,2-dimethylpropyl)[3,5-bi-1,2-oxazol]-3-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic+acid'>AYO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RORG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NCOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYO:(4S)-4-[4-cyclopropyl-5-(2,2-dimethylpropyl)[3,5-bi-1,2-oxazol]-3-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic+acid'>AYO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivx OCA], [http://pdbe.org/6ivx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ivx RCSB], [http://www.ebi.ac.uk/pdbsum/6ivx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivx OCA], [https://pdbe.org/6ivx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivx RCSB], [https://www.ebi.ac.uk/pdbsum/6ivx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6ivx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ivx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Adachi, T]]
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[[Category: Adachi T]]
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[[Category: Doi, S]]
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[[Category: Doi S]]
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[[Category: Noguchi, M]]
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[[Category: Noguchi M]]
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[[Category: Nomura, A]]
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[[Category: Nomura A]]
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[[Category: Immune system]]
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[[Category: Nuclear protein]]
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[[Category: Nuclear protein-inhibitor complex]]
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[[Category: Nuclear receptor]]
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[[Category: Ternary complex]]
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Current revision

Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.

PDB ID 6ivx

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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