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6iw3

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Current revision (09:53, 22 November 2023) (edit) (undo)
 
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==High resolution structure of Dvl2-DIX Y27W/C80S mutant==
==High resolution structure of Dvl2-DIX Y27W/C80S mutant==
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<StructureSection load='6iw3' size='340' side='right' caption='[[6iw3]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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<StructureSection load='6iw3' size='340' side='right'caption='[[6iw3]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6iw3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IW3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6iw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IW3 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iw3 OCA], [http://pdbe.org/6iw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iw3 RCSB], [http://www.ebi.ac.uk/pdbsum/6iw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iw3 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iw3 OCA], [https://pdbe.org/6iw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iw3 RCSB], [https://www.ebi.ac.uk/pdbsum/6iw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iw3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN]] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref>
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[https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Shibata, N]]
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[[Category: Homo sapiens]]
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[[Category: Yamanishi, K]]
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[[Category: Large Structures]]
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[[Category: Signaling protein]]
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[[Category: Shibata N]]
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[[Category: Wnt signalling]]
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[[Category: Yamanishi K]]

Current revision

High resolution structure of Dvl2-DIX Y27W/C80S mutant

PDB ID 6iw3

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