6jnp

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Current revision (10:16, 22 November 2023) (edit) (undo)
 
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<StructureSection load='6jnp' size='340' side='right'caption='[[6jnp]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
<StructureSection load='6jnp' size='340' side='right'caption='[[6jnp]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6jnp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JNP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JNP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6jnp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JNP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.261&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jnp OCA], [http://pdbe.org/6jnp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jnp RCSB], [http://www.ebi.ac.uk/pdbsum/6jnp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jnp ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jnp OCA], [https://pdbe.org/6jnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jnp RCSB], [https://www.ebi.ac.uk/pdbsum/6jnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jnp ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EXOT_PSEAE EXOT_PSEAE] Bifunctional effector protein that is secreted and delivered by the type III secretion system into eukaryotic target cells. The N-terminus encodes a GTPase-activating protein activity, whereas the C-terminus encodes an ADP-ribosyltransferase activity (PubMed:11298647). ADP-ribosylates several eukaryotic proteins including CT10 regulator of kinase (Crk) proteins (PubMed:12807879). In turn, induces atypical anoikis apoptosis by transforming Crk adaptor protein into a cytotoxin (PubMed:26020630). Affects host cell morphology by disrupting the actin cytoskeleton (PubMed:14688136). In addition to this activity, acts via its N-terminal region as a GTPase-activating protein (GAP) for host Rho GTPases including RhoA, Rac1, Cdc42 and Ras (PubMed:11895987). The GAP domain activity induces mitochondrial disruption in the target host cell by activating host caspases 3 and 9 that execute cellular death (PubMed:26451042). This activity also causes stress fiber disassembly (PubMed:11895987).<ref>PMID:11298647</ref> <ref>PMID:11895987</ref> <ref>PMID:12807879</ref> <ref>PMID:14688136</ref> <ref>PMID:26020630</ref> <ref>PMID:26451042</ref>
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==See Also==
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*[[Exoenzyme 3D structures|Exoenzyme 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Datta, S]]
 
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[[Category: Mondal, A]]
 
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[[Category: Chaperone]]
 
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[[Category: Effector]]
 
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[[Category: Effector-toxin]]
 
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[[Category: Exot]]
 
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[[Category: Exotoxin]]
 
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[[Category: Pseudomona]]
 
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Spc]]
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[[Category: Datta S]]
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[[Category: T3ss]]
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[[Category: Mondal A]]
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[[Category: Toxin]]
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Current revision

Structure of ExoT-SpcS Complex from Pseudomonas aeruginosa in 2.2 Angstrom

PDB ID 6jnp

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