6kee

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Current revision (10:31, 22 November 2023) (edit) (undo)
 
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==Crystal structure of BRD4 Bromodomain1 with an inhibitor==
==Crystal structure of BRD4 Bromodomain1 with an inhibitor==
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<StructureSection load='6kee' size='340' side='right'caption='[[6kee]]' scene=''>
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<StructureSection load='6kee' size='340' side='right'caption='[[6kee]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KEE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KEE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6kee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KEE FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kee OCA], [http://pdbe.org/6kee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kee RCSB], [http://www.ebi.ac.uk/pdbsum/6kee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kee ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1215465&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D7U:6-[2-[2,4-bis(fluoranyl)phenoxy]-5-(methylsulfonylmethyl)pyridin-3-yl]-8-methyl-2H-pyrrolo[1,2-a]pyrazin-1-one'>D7U</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kee OCA], [https://pdbe.org/6kee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kee RCSB], [https://www.ebi.ac.uk/pdbsum/6kee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kee ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen S]]
[[Category: Chen S]]

Current revision

Crystal structure of BRD4 Bromodomain1 with an inhibitor

PDB ID 6kee

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