6kot

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Current revision (10:38, 22 November 2023) (edit) (undo)
 
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<StructureSection load='6kot' size='340' side='right'caption='[[6kot]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='6kot' size='340' side='right'caption='[[6kot]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6kot]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KOT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6kot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KOT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DQ0:4-[3-[[2,6-bis(azanyl)-5-(3-chlorophenyl)pyrimidin-4-yl]methoxy]phenoxy]butanoic+acid'>DQ0</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.149&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kot OCA], [http://pdbe.org/6kot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kot RCSB], [http://www.ebi.ac.uk/pdbsum/6kot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kot ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DQ0:4-[3-[[2,6-bis(azanyl)-5-(3-chlorophenyl)pyrimidin-4-yl]methoxy]phenoxy]butanoic+acid'>DQ0</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kot OCA], [https://pdbe.org/6kot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kot RCSB], [https://www.ebi.ac.uk/pdbsum/6kot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kot ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
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[https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6kot" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6kot" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Vanichtanankul, J]]
 
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[[Category: Vitsupakorn, D]]
 
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[[Category: Inhibitor]]
 
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[[Category: Oxidoreductase]]
 
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Quadruple mutant dihydrofolate reductase]]
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[[Category: Vanichtanankul J]]
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[[Category: Transferase]]
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[[Category: Vitsupakorn D]]

Current revision

Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with B12128 and NADPH

PDB ID 6kot

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OCA

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