1ogq
From Proteopedia
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'''THE CRYSTAL STRUCTURE OF PGIP (POLYGALACTURONASE INHIBITING PROTEIN), A LEUCINE RICH REPEAT PROTEIN INVOLVED IN PLANT DEFENSE''' | '''THE CRYSTAL STRUCTURE OF PGIP (POLYGALACTURONASE INHIBITING PROTEIN), A LEUCINE RICH REPEAT PROTEIN INVOLVED IN PLANT DEFENSE''' | ||
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[[Category: Savino, C.]] | [[Category: Savino, C.]] | ||
[[Category: Tsernoglou, D.]] | [[Category: Tsernoglou, D.]] | ||
| - | [[Category: | + | [[Category: Inhibitor]] |
| - | [[Category: | + | [[Category: Polygalacturonase inhibiting protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:49:30 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:49, 3 May 2008
THE CRYSTAL STRUCTURE OF PGIP (POLYGALACTURONASE INHIBITING PROTEIN), A LEUCINE RICH REPEAT PROTEIN INVOLVED IN PLANT DEFENSE
Overview
Polygalacturonase-inhibiting proteins (PGIPs) are plant cell wall proteins that protect plants from fungal invasion. They interact with endopolygalacturonases secreted by phytopathogenic fungi, inhibit their enzymatic activity, and favor the accumulation of oligogalacturonides, which activate plant defense responses. PGIPs are members of the leucine-rich repeat (LRR) protein family that in plants play crucial roles in development, defense against pathogens, and recognition of beneficial microbes. Here we report the crystal structure at 1.7-A resolution of a PGIP from Phaseolus vulgaris. The structure is characterized by the presence of two beta-sheets instead of the single one originally predicted by modeling studies. The structure also reveals a negatively charged surface on the LRR concave face, likely involved in binding polygalacturonases. The structural information on PGIP provides a basis for designing more efficient inhibitors for plant protection.
About this Structure
1OGQ is a Single protein structure of sequence from Phaseolus vulgaris. Full crystallographic information is available from OCA.
Reference
The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense., Di Matteo A, Federici L, Mattei B, Salvi G, Johnson KA, Savino C, De Lorenzo G, Tsernoglou D, Cervone F, Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10124-8. Epub 2003 Aug 6. PMID:12904578 Page seeded by OCA on Sat May 3 03:49:30 2008
