6lfl

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<StructureSection load='6lfl' size='340' side='right'caption='[[6lfl]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='6lfl' size='340' side='right'caption='[[6lfl]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6lfl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LFL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LFL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6lfl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LFL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EBX:4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide'>EBX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CXCR2, IL8RB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EBX:4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide'>EBX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lfl OCA], [http://pdbe.org/6lfl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lfl RCSB], [http://www.ebi.ac.uk/pdbsum/6lfl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lfl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lfl OCA], [https://pdbe.org/6lfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lfl RCSB], [https://www.ebi.ac.uk/pdbsum/6lfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lfl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN]] Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency.
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[https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN]] Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
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[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6lfl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6lfl" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CXC chemokine receptor|CXC chemokine receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hua, T]]
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[[Category: Pyrococcus abyssi GE5]]
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[[Category: Liu, K W]]
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[[Category: Hua T]]
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[[Category: Liu, Z J]]
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[[Category: Liu KW]]
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[[Category: Wu, L J]]
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[[Category: Liu ZJ]]
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[[Category: G protein-coupled receptor]]
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[[Category: Wu LJ]]
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[[Category: Membrane protein]]
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Revision as of 10:59, 22 November 2023

Crystal structure of a class A GPCR

PDB ID 6lfl

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