8poe
From Proteopedia
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(Replacing page with ''''Unreleased structure''' The entry 8poe is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures') |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of tissue-specific lipid scramblase ATG9B homotrimer, refined with C3 symmetry applied== | |
| - | + | <StructureSection load='8poe' size='340' side='right'caption='[[8poe]], [[Resolution|resolution]] 4.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8poe]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8POE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8POE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8poe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8poe OCA], [https://pdbe.org/8poe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8poe RCSB], [https://www.ebi.ac.uk/pdbsum/8poe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8poe ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ATG9B_HUMAN ATG9B_HUMAN] Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity).[UniProtKB:Q68FE2][UniProtKB:Q7Z3C6] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cherepanov P]] | ||
| + | [[Category: Chiduza GN]] | ||
| + | [[Category: Pye VE]] | ||
| + | [[Category: Tooze SA]] | ||
Current revision
Structure of tissue-specific lipid scramblase ATG9B homotrimer, refined with C3 symmetry applied
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