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5nxl

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Current revision (12:15, 22 November 2023) (edit) (undo)
 
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==Formylglycine generating enzyme from T. curvata in complex with Ag(I)==
==Formylglycine generating enzyme from T. curvata in complex with Ag(I)==
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<StructureSection load='5nxl' size='340' side='right' caption='[[5nxl]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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<StructureSection load='5nxl' size='340' side='right'caption='[[5nxl]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nxl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thecd Thecd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NXL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermomonospora_curvata_DSM_43183 Thermomonospora curvata DSM 43183]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NXL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AG:SILVER+ION'>AG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tcur_4811 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=471852 THECD])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AG:SILVER+ION'>AG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxl OCA], [https://pdbe.org/5nxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nxl RCSB], [https://www.ebi.ac.uk/pdbsum/5nxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxl OCA], [http://pdbe.org/5nxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxl RCSB], [http://www.ebi.ac.uk/pdbsum/5nxl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxl ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FGE_THECD FGE_THECD] Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile.<ref>PMID:26403223</ref> <ref>PMID:27862795</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Thecd]]
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[[Category: Thermomonospora curvata DSM 43183]]
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[[Category: Knop, M]]
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[[Category: Knop M]]
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[[Category: Meury, M]]
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[[Category: Meury M]]
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[[Category: Seebeck, F P]]
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[[Category: Seebeck FP]]
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[[Category: Copper enzyme]]
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[[Category: Formylglycine generating enzyme]]
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[[Category: Metal-binding]]
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[[Category: Silver complex]]
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[[Category: Sulfatase modification]]
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[[Category: Transferase]]
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Current revision

Formylglycine generating enzyme from T. curvata in complex with Ag(I)

PDB ID 5nxl

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