1oio

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[[Image:1oio.jpg|left|200px]]
[[Image:1oio.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1oio |SIZE=350|CAPTION= <scene name='initialview01'>1oio</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1oio", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1oio| PDB=1oio | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oio OCA], [http://www.ebi.ac.uk/pdbsum/1oio PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oio RCSB]</span>
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}}
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'''GAFD (F17C-TYPE) FIMBRIAL ADHESIN FROM ESCHERICHIA COLI'''
'''GAFD (F17C-TYPE) FIMBRIAL ADHESIN FROM ESCHERICHIA COLI'''
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[[Category: Tanskanen, J.]]
[[Category: Tanskanen, J.]]
[[Category: Westerlund-Wikstrom, B.]]
[[Category: Westerlund-Wikstrom, B.]]
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[[Category: adhesin]]
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[[Category: Adhesin]]
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[[Category: glcnac binding lectin]]
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[[Category: Glcnac binding lectin]]
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[[Category: n-acetyl-d-glucosamine binding]]
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[[Category: N-acetyl-d-glucosamine binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:53:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:45:53 2008''
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Revision as of 00:53, 3 May 2008

Image:1oio.jpg

Template:STRUCTURE 1oio

GAFD (F17C-TYPE) FIMBRIAL ADHESIN FROM ESCHERICHIA COLI


Overview

GafD in Escherichia coli G (F17) fimbriae is associated with diarrheal disease, and the structure of the ligand-binding domain, GafD1-178, has been determined at 1.7A resolution in the presence of the receptor sugar N-acetyl-D-glucosamine. The overall fold is a beta-barrel jelly-roll fold. The ligand-binding site was identified and localized to the side of the molecule. Receptor binding is mediated by side-chain as well main-chain interactions. Ala43-Asn44, Ser116-Thr117 form the sugar acetamide specificity pocket, while Asp88 confers tight binding and Trp109 appears to position the ligand. There is a disulfide bond that rigidifies the acetamide specificity pocket. The three fimbrial lectins, GafD, FimH and PapG share similar beta-barrel folds but display different ligand-binding regions and disulfide-bond patterns. We suggest an evolutionary path for the evolution of the very diverse fimbrial lectins from a common ancestral fold.

About this Structure

1OIO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structural basis of receptor-binding by Escherichia coli associated with diarrhea and septicemia., Merckel MC, Tanskanen J, Edelman S, Westerlund-Wikstrom B, Korhonen TK, Goldman A, J Mol Biol. 2003 Aug 22;331(4):897-905. PMID:12909017 Page seeded by OCA on Sat May 3 03:53:45 2008

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