1ojg
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1ojg.jpg|left|200px]] | [[Image:1ojg.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1ojg", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1ojg| PDB=1ojg | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''SENSORY DOMAIN OF THE MEMBRANEOUS TWO-COMPONENT FUMARATE SENSOR DCUS OF E. COLI''' | '''SENSORY DOMAIN OF THE MEMBRANEOUS TWO-COMPONENT FUMARATE SENSOR DCUS OF E. COLI''' | ||
| Line 34: | Line 31: | ||
[[Category: Zientz, E.]] | [[Category: Zientz, E.]] | ||
[[Category: Zweckstetter, M.]] | [[Category: Zweckstetter, M.]] | ||
| - | [[Category: | + | [[Category: Dcus]] |
| - | [[Category: | + | [[Category: Fumarate]] |
| - | [[Category: | + | [[Category: Histidine kinase]] |
| - | [[Category: | + | [[Category: Transferase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:55:27 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:55, 3 May 2008
SENSORY DOMAIN OF THE MEMBRANEOUS TWO-COMPONENT FUMARATE SENSOR DCUS OF E. COLI
Overview
The structure of the water-soluble, periplasmic domain of the fumarate sensor DcuS (DcuS-pd) has been determined by NMR spectroscopy in solution. DcuS is a prototype for a sensory histidine kinase with transmembrane signal transfer. DcuS belongs to the CitA family of sensors that are specific for sensing di- and tricarboxylates. The periplasmic domain is folded autonomously and shows helices at the N and the C terminus, suggesting direct linking or connection to helices in the two transmembrane regions. The structure constitutes a novel fold. The nearest structural neighbor is the Per-Arnt-Sim domain of the photoactive yellow protein that binds small molecules covalently. Residues Arg107, His110, and Arg147 are essential for fumarate sensing and are found clustered together. The structure constitutes the first periplasmic domain of a two component sensory system and is distinctly different from the aspartate sensory domain of the Tar chemotaxis sensor.
About this Structure
1OJG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli., Pappalardo L, Janausch IG, Vijayan V, Zientz E, Junker J, Peti W, Zweckstetter M, Unden G, Griesinger C, J Biol Chem. 2003 Oct 3;278(40):39185-8. Epub 2003 Aug 7. PMID:12907689 Page seeded by OCA on Sat May 3 03:55:27 2008
