8pvb

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'''Unreleased structure'''
 
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The entry 8pvb is ON HOLD until Paper Publication
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==Structure of GABAAR determined by cryoEM at 100 keV==
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<StructureSection load='8pvb' size='340' side='right'caption='[[8pvb]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8pvb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PVB FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene>, <scene name='pdbligand=V8D:ethyl+1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate'>V8D</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pvb OCA], [https://pdbe.org/8pvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pvb RCSB], [https://www.ebi.ac.uk/pdbsum/8pvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pvb ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
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[[Category: Large Structures]]
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[[Category: Cannone G]]
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[[Category: Chen S]]
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[[Category: Dalby J]]
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[[Category: Dickerson JL]]
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[[Category: El-Gomati MM]]
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[[Category: Gittins O]]
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[[Category: Henderson R]]
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[[Category: Hutchings KA]]
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[[Category: Lee Y]]
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[[Category: McMullan G]]
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[[Category: Meffert M]]
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[[Category: Mihaylov D]]
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[[Category: Naydenova K]]
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[[Category: Peet MJ]]
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[[Category: Russo CJ]]
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[[Category: Schulze-Briese C]]
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[[Category: Sobhy M]]
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[[Category: Wells T]]
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[[Category: Wilson H]]
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[[Category: Yamashita K]]

Revision as of 14:05, 29 November 2023

Structure of GABAAR determined by cryoEM at 100 keV

PDB ID 8pvb

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