8pve
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of AHIR determined by cryoEM at 100 keV== | |
| - | + | <StructureSection load='8pve' size='340' side='right'caption='[[8pve]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8pve]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PVE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pve OCA], [https://pdbe.org/8pve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pve RCSB], [https://www.ebi.ac.uk/pdbsum/8pve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pve ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ILVC_THET2 ILVC_THET2] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thermus thermophilus]] | ||
| + | [[Category: Cannone G]] | ||
| + | [[Category: Chen S]] | ||
| + | [[Category: Dalby J]] | ||
| + | [[Category: Dickerson JL]] | ||
| + | [[Category: El-Gomati MM]] | ||
| + | [[Category: Gittins O]] | ||
| + | [[Category: Henderson R]] | ||
| + | [[Category: Hutchings KA]] | ||
| + | [[Category: Lee Y]] | ||
| + | [[Category: McMullan G]] | ||
| + | [[Category: Meffert M]] | ||
| + | [[Category: Mihaylov D]] | ||
| + | [[Category: Naydenova K]] | ||
| + | [[Category: Peet MJ]] | ||
| + | [[Category: Russo CJ]] | ||
| + | [[Category: Schulze-Briese C]] | ||
| + | [[Category: Sobhy M]] | ||
| + | [[Category: Wells T]] | ||
| + | [[Category: Wilson H]] | ||
| + | [[Category: Yamashita K]] | ||
Current revision
Structure of AHIR determined by cryoEM at 100 keV
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Categories: Large Structures | Thermus thermophilus | Cannone G | Chen S | Dalby J | Dickerson JL | El-Gomati MM | Gittins O | Henderson R | Hutchings KA | Lee Y | McMullan G | Meffert M | Mihaylov D | Naydenova K | Peet MJ | Russo CJ | Schulze-Briese C | Sobhy M | Wells T | Wilson H | Yamashita K
