8s9e

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'''Unreleased structure'''
 
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The entry 8s9e is ON HOLD until Paper Publication
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==Solution structure of jarastatin (rJast), a disintegrin from Bothrops jararaca==
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<StructureSection load='8s9e' size='340' side='right'caption='[[8s9e]]' scene=''>
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Authors: Vasconcelos, A.A., Estrada, J.E.C., Zingali, R.B., Almeida, F.C.L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8s9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararaca Bothrops jararaca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S9E FirstGlance]. <br>
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Description: Solution structure of jarastatin (rJast), a disintegrin from Bothrops jararaca
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s9e OCA], [https://pdbe.org/8s9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s9e RCSB], [https://www.ebi.ac.uk/pdbsum/8s9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s9e ProSAT]</span></td></tr>
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[[Category: Zingali, R.B]]
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</table>
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[[Category: Estrada, J.E.C]]
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== Function ==
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[[Category: Vasconcelos, A.A]]
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[https://www.uniprot.org/uniprot/VM2JA_BOTJA VM2JA_BOTJA] Binds alpha-5/beta-1 (ITGAV/ITGB1), alpha-V/beta-3 (ITGAV/ITGB3) and alpha-M/beta-2 (ITGAM/ITGB2) integrins. Is a potent inhibitor of platelet aggregation induced by ADP, collagen, and thrombin. Induces neutrophil chemotaxis and inhibits the chemotaxis of human neutrophils toward fMLP, IL-8, and jarastatin itself. Directly activates an integrin-coupled signaling and modulate the MAPK pathway in different ways, leading the neutrophils to express different functional response. Jarastatin-treated neutrophils accumulates F-actin at the plasmalemma. Induces PTK2/FAK1 and phosphoinositide 3-kinase (PI3K) activation. Induces Erk-2 translocation to nucleus and a delay of the spontaneous apoptosis of neutrophils. Increases the IL-8 mRNA levels in neutrophils. When injected simultaneously with melanoma cells in mice, jarastatin, flavoridin (FL) and kistrin (KR), significantly reduce tumor lung colonization. Jarastatin inhibits B16F10 cell growth in vitro. When it interacts with melanoma cells, it induces actin cytoskeleton rearrangement, increasing actin polymerization and PTK2/FAK1 phosphorylation. Interferes with NF-kappaB translocation in melanoma cells.<ref>PMID:10471323</ref> <ref>PMID:14697344</ref> <ref>PMID:17854854</ref>
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[[Category: Almeida, F.C.L]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bothrops jararaca]]
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[[Category: Large Structures]]
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[[Category: Almeida FCL]]
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[[Category: Estrada JEC]]
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[[Category: Vasconcelos AA]]
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[[Category: Zingali RB]]

Revision as of 14:08, 29 November 2023

Solution structure of jarastatin (rJast), a disintegrin from Bothrops jararaca

PDB ID 8s9e

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