8t5q

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Current revision (14:10, 29 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8t5q is ON HOLD until Paper Publication
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==SARS-CoV-2 ORF3a peptide in complex with TRAF2 TRAF domain==
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<StructureSection load='8t5q' size='340' side='right'caption='[[8t5q]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Busscher, B.M., Xiao, T.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8t5q]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T5Q FirstGlance]. <br>
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Description: SARS-CoV-2 ORF3a peptide in complex with TRAF2 TRAF domain
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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[[Category: Busscher, B.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t5q OCA], [https://pdbe.org/8t5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t5q RCSB], [https://www.ebi.ac.uk/pdbsum/8t5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t5q ProSAT]</span></td></tr>
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[[Category: Xiao, T.S]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRAF2_HUMAN TRAF2_HUMAN] Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.<ref>PMID:10346818</ref> <ref>PMID:11907583</ref> <ref>PMID:12917689</ref> <ref>PMID:15383523</ref> <ref>PMID:19506082</ref> <ref>PMID:19150425</ref> <ref>PMID:18981220</ref> <ref>PMID:19918265</ref> <ref>PMID:20064526</ref> <ref>PMID:19937093</ref> <ref>PMID:20047764</ref> <ref>PMID:20577214</ref> <ref>PMID:19810754</ref> <ref>PMID:20385093</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Severe acute respiratory syndrome coronavirus 2]]
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[[Category: Busscher BM]]
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[[Category: Xiao TS]]

Current revision

SARS-CoV-2 ORF3a peptide in complex with TRAF2 TRAF domain

PDB ID 8t5q

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